Physical mapping of EMR1 and CD97 in human Chromosome 19 and assignment of Cd97 to mouse Chromosome 8 suggest an ancient genomic duplication

Physical mapping of EMR1 and CD97 in human Chromosome 19 and assignment of Cd97 to mouse... Mammalian Genome 10, 1039–1040 (1999). Incorporating Mouse Genome © Springer-Verlag New York Inc. 1999 Physical mapping of EMR1 and CD97 in human Chromosome 19 and assignment of Cd97 to mouse Chromosome 8 suggest an ancient genomic duplication 1,2 3 1 1 Ethan A. Carver, Jo ¨ rg Hamann, Anne S. Olsen, Lisa Stubbs Biology and Biotechnology Research Program, Lawrence Livermore National Laboratory, P.O. Box 808, L-452, Livermore, California 94550, USA University of Tennessee–Oak Ridge School of Biomedical Sciences, Oak Ridge National Laboratory, 1060 Commerce Park, Oak Ridge, Tennessee 37830-8026, USA CLB and Laboratory for Experimental and Clinical Immunology, Academic Medical Centre, University of Amsterdam, Plesmanlaan 125, 1066 CX Amsterdam, The Netherlands Received: 10 March 1999 / Accepted: 8 June 1999 EMR1 and CD97 belong to the EGF-TM7 family of nonclassical seven-span transmembrane receptors, members of which are ex- pressed primarily in the immune system. The membrane-spanning regions of CD97, EMR1, and other EGF-TM7 proteins show sig- nificant homology to the secretin receptor superfamily. However, unlike this group of peptide hormone receptors, EMR1 and CD97 have extended extracellular portions that possess several EGF do- mains at the N-terminus (McKnight and Gordon 1998). The EGF domain region can function as a http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Mammalian Genome Springer Journals

Physical mapping of EMR1 and CD97 in human Chromosome 19 and assignment of Cd97 to mouse Chromosome 8 suggest an ancient genomic duplication

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Publisher
Springer Journals
Copyright
Copyright © 1999 by Springer-Verlag New York Inc.
Subject
Life Sciences; Cell Biology; Animal Genetics and Genomics; Human Genetics
ISSN
0938-8990
eISSN
1432-1777
D.O.I.
10.1007/s003359901157
Publisher site
See Article on Publisher Site

Abstract

Mammalian Genome 10, 1039–1040 (1999). Incorporating Mouse Genome © Springer-Verlag New York Inc. 1999 Physical mapping of EMR1 and CD97 in human Chromosome 19 and assignment of Cd97 to mouse Chromosome 8 suggest an ancient genomic duplication 1,2 3 1 1 Ethan A. Carver, Jo ¨ rg Hamann, Anne S. Olsen, Lisa Stubbs Biology and Biotechnology Research Program, Lawrence Livermore National Laboratory, P.O. Box 808, L-452, Livermore, California 94550, USA University of Tennessee–Oak Ridge School of Biomedical Sciences, Oak Ridge National Laboratory, 1060 Commerce Park, Oak Ridge, Tennessee 37830-8026, USA CLB and Laboratory for Experimental and Clinical Immunology, Academic Medical Centre, University of Amsterdam, Plesmanlaan 125, 1066 CX Amsterdam, The Netherlands Received: 10 March 1999 / Accepted: 8 June 1999 EMR1 and CD97 belong to the EGF-TM7 family of nonclassical seven-span transmembrane receptors, members of which are ex- pressed primarily in the immune system. The membrane-spanning regions of CD97, EMR1, and other EGF-TM7 proteins show sig- nificant homology to the secretin receptor superfamily. However, unlike this group of peptide hormone receptors, EMR1 and CD97 have extended extracellular portions that possess several EGF do- mains at the N-terminus (McKnight and Gordon 1998). The EGF domain region can function as a

Journal

Mammalian GenomeSpringer Journals

Published: Oct 1, 1999

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