Mammalian Genome 10, 1039–1040 (1999). Incorporating Mouse Genome © Springer-Verlag New York Inc. 1999 Physical mapping of EMR1 and CD97 in human Chromosome 19 and assignment of Cd97 to mouse Chromosome 8 suggest an ancient genomic duplication 1,2 3 1 1 Ethan A. Carver, Jo ¨ rg Hamann, Anne S. Olsen, Lisa Stubbs Biology and Biotechnology Research Program, Lawrence Livermore National Laboratory, P.O. Box 808, L-452, Livermore, California 94550, USA University of Tennessee–Oak Ridge School of Biomedical Sciences, Oak Ridge National Laboratory, 1060 Commerce Park, Oak Ridge, Tennessee 37830-8026, USA CLB and Laboratory for Experimental and Clinical Immunology, Academic Medical Centre, University of Amsterdam, Plesmanlaan 125, 1066 CX Amsterdam, The Netherlands Received: 10 March 1999 / Accepted: 8 June 1999 EMR1 and CD97 belong to the EGF-TM7 family of nonclassical seven-span transmembrane receptors, members of which are ex- pressed primarily in the immune system. The membrane-spanning regions of CD97, EMR1, and other EGF-TM7 proteins show sig- nificant homology to the secretin receptor superfamily. However, unlike this group of peptide hormone receptors, EMR1 and CD97 have extended extracellular portions that possess several EGF do- mains at the N-terminus (McKnight and Gordon 1998). The EGF domain region can function as a
Mammalian Genome – Springer Journals
Published: Oct 1, 1999
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