Physical map and localization of the human casein gene locus

Physical map and localization of the human casein gene locus Mammalian Genome 8, 285-286 (1997). eJ~o/J~e 9 Springer-Verlag New York Inc. 1997 M. Rijnkels, 1'2'* E. Meershoek, 2 H.A. de Boer, 1 F.R. Pieper 2 ~Medical Biotechnology Department, Leiden Institute of Chemistry, Leiden University, P.O. Box 9502, 2300 RA Leiden, The Netherlands 2pharming B.V., Niels Bohrweg 11-13, 2333 CA Leiden, The Netherlands Received: 30 June 1996 / Accepted: 8 December 1996 lacked a-like caseins and only [3- and K-casein were present. How- Caseins are present in milk of all mammals; their primary function ever, the presence of an asl-like protein has been reported (Cav- is to provide the suckling infant with essential amino acids, cal- aletto et al. 1994; Rasmussen et al. 1995), and subsequently 3 cium, and phosphate. They are encoded by single-copy genes, asl-casein mRNA transcripts have been isolated (Johnsen et al. members of a multigene family. The organization of the bovine 1995). These transcripts show 100% homology except for a 3- and and mouse casein gene loci has been determined previously and 24-bp deletion in transcripts type 2 and 3, respectively (Johnsen et was shown to be highly similar (Rijnkels et al. 1997a, 1997b). The al. 1995). This can be attributed to differential processing of pre- Mammalian Genome Springer Journals

Physical map and localization of the human casein gene locus

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Copyright © 1997 by Springer-Verlag
Life Sciences; Cell Biology; Anatomy; Zoology
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