Physical assignment of glucagon and nebulin in cattle, sheep, and goat

Physical assignment of glucagon and nebulin in cattle, sheep, and goat Mammalian Genome 8,428-429 (1997). 9 Springer-Verlag New York Inc. 1997 Nestor L. Lopez-Corrales, T.S. Sonstegard, T.P.L. Smith, C.W. Beattie U.S. Department of Agriculture, Agricultural Research Service, Roman L. Hruska U.S. Meat Animal Research Center, Spur 18D, P.O. Box 166, Clay Center, Nebraska 68933-0166, USA Received: 4 October 1996 / Accepted: 20 January 1997 Introduction Nebulin (NEB) belongs to a family of large molecular weight proteins (600-900 kD) present in various skeletal muscles. They constitute a set of inextensible filaments anchored at the Z line (Wang and Wright 1988) that act as a length-regulating template for thin filaments (Kruger et al. 1991). Nebulin was initially as- signed to 2q31-q32 (Zeviani et al. 1988) in humans, and more recently to 2q24.1-q24.2 in a synteny group that covers 5-10 cM Fig. 1. Fluorescence in situ hybridization of glucagon (G) and nebulin (N) on human Chromosome (Chr) 2 conserved since the divergence of in cattle (c), sheep (s) and goat (g). (Left: R-banded chromosomes). R- humans and rodents (Rossi et al. 1994). banded chromosomes were obtained according to Lemieux and coworkers Glucagon (GCG), a polypeptide hormone found in the pan- (1992). FISH, digital image, and probes localization protocol were devel- creas and gut Mammalian Genome Springer Journals

Physical assignment of glucagon and nebulin in cattle, sheep, and goat

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Copyright © 1997 by Springer-Verlag
Life Sciences; Cell Biology; Anatomy; Zoology
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