Phylogenetic origin of a secondary pathway: the case of pyrrolizidine alkaloids

Phylogenetic origin of a secondary pathway: the case of pyrrolizidine alkaloids Recent studies have revealed high sequence similarity between homospermidine synthase (HSS), the first pathway-specific enzyme in the biosynthesis of pyrrolizidine alkaloids, a class of sporadically occurring plant defence compounds, and deoxyhypusine synthase (DHS), a ubiquitous enzyme involved in the post-translational activation of the eukaryotic initiation factor 5A (eIF5A). The recruitment of DHS during the evolution of the alkaloid pathway is discussed and interpreted as evolution by change of function. Plant Molecular Biology Springer Journals

Phylogenetic origin of a secondary pathway: the case of pyrrolizidine alkaloids

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Kluwer Academic Publishers
Copyright © 2000 by Kluwer Academic Publishers
Life Sciences; Biochemistry, general; Plant Sciences; Plant Pathology
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