Different genomic regions replicate at a different fixed time during the S phase. Late-replicating sequences are often underreplicated in the Drosophila salivary-gland polytene chromosomes. The SuUR gene, whose mutation changes the replication time of late-replicating regions in salivary-gland cells, has been identified in Drosophila melanogaster. The SUUR protein lacks homologs by a BLAST search, and only moderate similarity is observed between its N-terminal part and chromatin-remodeling proteins of the SWI2/SNF2 family. The gene and the protein were analyzed in insects. Orthologs of the SuUR gene were found in all annotated Drosophila species. The number of amino acid substitutions in the SUUR protein proved to be extremely high, corresponding to that of fast-evolving genes. Orthologs with low homology were found in mosquitoes Anopheles gambiae, Aedes aegypti, and Culex quinquefasciatus. No orthologs of the SuUR gene were detected beyond Diptera.
Russian Journal of Genetics – Springer Journals
Published: Sep 30, 2010
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