Photochemical route for the synthesis of novel 2-monosubstituted pyrido[2,3-d]pyrimidines by palladium-catalyzed cross-coupling reactions

Photochemical route for the synthesis of novel 2-monosubstituted pyrido[2,3-d]pyrimidines by... Chem. Pap. (2018) 72:697–701 https://doi.org/10.1007/s11696-017-0325-2 ORIGINAL PAPER Photochemical route for the synthesis of novel 2-monosubstituted pyrido[2,3-d]pyrimidines by palladium-catalyzed cross-coupling reactions 1 2 Yassine Riadi Mohammed Geesi Received: 21 May 2017 / Accepted: 20 October 2017 / Published online: 28 October 2017 Institute of Chemistry, Slovak Academy of Sciences 2017 Abstract A novel and effective route for the synthesis of Graphical abstract 2-monosubstituted pyrido[2,3-d]pyrimidines is reported starting from the corresponding 2-halogeno- and 2-methylsulfanyl-pyrido[2,3-d]pyrimidine through a palla- dium-catalyzed cross-coupling has been described. The reaction involved original halogen discrimination under visible light as an alternative source of energy. Alterna- tively, monoarylated compounds were elaborated from 2-halogeno pyrido[2,3-d]pyrimidine by C2 chlorine further displacement and from 2-methylsulfanyl-pyrido[2,3- Keywords Palladium  Pyridopyrimidines  Cross- d]pyrimidine by C-alkylsulfanyl release. We have descri- coupling  Halogen discrimination  Monoarylated  Visible bed the first synthesis of mono substituted pyrido[2,3- light d]pyrimidine series using a two strategies using visible light as a powerful synthetic tool for the preparation of focused libraries of biologically active compounds. The use Introduction of available starting materials, easy reaction conditions and catalytic processes combined with high yields of products The discovery and continuing evolution of plladium-cat- are the main outcome of this method. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Chemical Papers Springer Journals

Photochemical route for the synthesis of novel 2-monosubstituted pyrido[2,3-d]pyrimidines by palladium-catalyzed cross-coupling reactions

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Publisher
Springer Journals
Copyright
Copyright © 2017 by Institute of Chemistry, Slovak Academy of Sciences
Subject
Chemistry; Chemistry/Food Science, general; Industrial Chemistry/Chemical Engineering; Biochemistry, general; Medicinal Chemistry; Materials Science, general; Biotechnology
ISSN
0366-6352
eISSN
1336-9075
D.O.I.
10.1007/s11696-017-0325-2
Publisher site
See Article on Publisher Site

Abstract

Chem. Pap. (2018) 72:697–701 https://doi.org/10.1007/s11696-017-0325-2 ORIGINAL PAPER Photochemical route for the synthesis of novel 2-monosubstituted pyrido[2,3-d]pyrimidines by palladium-catalyzed cross-coupling reactions 1 2 Yassine Riadi Mohammed Geesi Received: 21 May 2017 / Accepted: 20 October 2017 / Published online: 28 October 2017 Institute of Chemistry, Slovak Academy of Sciences 2017 Abstract A novel and effective route for the synthesis of Graphical abstract 2-monosubstituted pyrido[2,3-d]pyrimidines is reported starting from the corresponding 2-halogeno- and 2-methylsulfanyl-pyrido[2,3-d]pyrimidine through a palla- dium-catalyzed cross-coupling has been described. The reaction involved original halogen discrimination under visible light as an alternative source of energy. Alterna- tively, monoarylated compounds were elaborated from 2-halogeno pyrido[2,3-d]pyrimidine by C2 chlorine further displacement and from 2-methylsulfanyl-pyrido[2,3- Keywords Palladium  Pyridopyrimidines  Cross- d]pyrimidine by C-alkylsulfanyl release. We have descri- coupling  Halogen discrimination  Monoarylated  Visible bed the first synthesis of mono substituted pyrido[2,3- light d]pyrimidine series using a two strategies using visible light as a powerful synthetic tool for the preparation of focused libraries of biologically active compounds. The use Introduction of available starting materials, easy reaction conditions and catalytic processes combined with high yields of products The discovery and continuing evolution of plladium-cat- are the main outcome of this method.

Journal

Chemical PapersSpringer Journals

Published: Oct 28, 2017

References

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