Phloretin-Induced Reduction in Dipole Potential of Sterol-Containing Bilayers

Phloretin-Induced Reduction in Dipole Potential of Sterol-Containing Bilayers The phloretin-induced reduction in the dipole potential of planar lipid bilayers containing cholesterol, ergosterol, stigmasterol, 7-dehydrocholesterol and 5α-androstan-3β-ol was investigated. It is shown that effects depend on the type and concentration of membrane sterol. It is supposed that the effectiveness of phloretin in reducing the dipole potential of the bilayers that contain cholesterol, ergosterol and 7-dehydrocholesterol correlates with the ordering and condensing effects. The role of the concentration-dependent ability of different sterols to promote lateral heterogeneity in membranes is also discussed. The Journal of Membrane Biology Springer Journals

Phloretin-Induced Reduction in Dipole Potential of Sterol-Containing Bilayers

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Springer US
Copyright © 2013 by Springer Science+Business Media New York
Life Sciences; Biochemistry, general; Human Physiology
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