Reactions 1704, p307 - 2 Jun 2018 Gingival overgrowth: case report In a study of 24 epileptic patients, one patient [age and sex not stated] was described, who developed gingival overgrowth during treatment with phenytoin [route and dosage not stated]. The patient had a diagnosis of epilepsy, for which, the patient received phenytoin. Following the phenytoin treatment, the patient had gingival overgrowth. It was considered as phenytoin-induced gingival overgrowth (PiGO) [duration of treatment to reaction onset and outcome not stated]. Author comment: "Drugs such as [ciclosporin], phenytoin,and nifedipine are the most common causes of gingival overgrowth. Phenytoin,a widely used anti-epileptic drug,has been shown to induce gingival overgrowth by its interaction with epithelial keratinocytes, a subpopulation of "sensitive" fibroblasts, and collagen." Margiotti K, et al. Lack of pathogenic mutations in SOS1 gene in phenytoin- induced gingival overgrowth patients. Archives of Oral Biology 80: 160-163, Aug 2017. Available from: URL: http://doi.org/10.1016/j.archoralbio.2017.04.002 - Italy 803324026 0114-9954/18/1704-0001/$14.95 Adis © 2018 Springer International Publishing AG. All rights reserved Reactions 2 Jun 2018 No. 1704
Reactions Weekly – Springer Journals
Published: Jun 2, 2018
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