Phenylethanoid glycoside from Forsythia koreana (Oleaceae) flowers shows a neuroprotective effect

Phenylethanoid glycoside from Forsythia koreana (Oleaceae) flowers shows a neuroprotective effect A repeated column chromatography for Forsythia koreana Nakai. flowers afforded a phenylethane glycoside, which was identified as 8 -(3,4-dihydroxyphenyl)ethyl-O-a-L-rhamnopyranosyl-(1 ? 4)-2-O-(E)-caffeoyl-a-L-arabinopyranoside 1 13 based on spectroscopic analyses of 1D NMR ( H-NMR, C-NMR, DEPT), 2D NMR (gCOSY, gHSQC, gHMBC), FAB/ MS, specific rotation, and IR spectrometry. This compound was isolated from F. koreana flower for the first time in this study. The compound showed scavenge activities in ORAC and DPPH radicals with the values of 0.83 ± 0.01 and 84.66 ± 0.75% (at the concentration of 500 ppm), respectively. It also inhibited production of NO for RAW 264.7 stimulated by LPS and protected oxidative stress induced by glutamate in HT22-immortalized hippocampal. The IC on inhibition of NO production and EC value on protective efficacy of oxidative stress were 78.72 ± 1.43 lM and 176.25 ± 7.23 lM, respectively. These results demonstrate that the phenylethanoid glycoside might be useful as a neu- roprotective agent because of their antioxidant, anti-inflammatory, and neuroprotective effects. Keywords 8 -(3,4-Dihydroxyphenyl)ethyl-O-a-L-rhamnopyranosyl-(1 ? 4)-2-O-(E)-caffeoyl-a-L-arabinopyranoside Anti-inflammation  Antioxidation  NO production 1 Introduction derived therefrom (Newman and Cragg 2007; Orhan 2012). Especially, pharmacological active materials derived from Even though most drugs currently commercially used in botanical galenicals have http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Brazilian Journal of Botany Springer Journals

Phenylethanoid glycoside from Forsythia koreana (Oleaceae) flowers shows a neuroprotective effect

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Publisher
Springer International Publishing
Copyright
Copyright © 2018 by Botanical Society of Sao Paulo
Subject
Life Sciences; Plant Systematics/Taxonomy/Biogeography
ISSN
0100-8404
eISSN
1806-9959
D.O.I.
10.1007/s40415-018-0468-6
Publisher site
See Article on Publisher Site

Abstract

A repeated column chromatography for Forsythia koreana Nakai. flowers afforded a phenylethane glycoside, which was identified as 8 -(3,4-dihydroxyphenyl)ethyl-O-a-L-rhamnopyranosyl-(1 ? 4)-2-O-(E)-caffeoyl-a-L-arabinopyranoside 1 13 based on spectroscopic analyses of 1D NMR ( H-NMR, C-NMR, DEPT), 2D NMR (gCOSY, gHSQC, gHMBC), FAB/ MS, specific rotation, and IR spectrometry. This compound was isolated from F. koreana flower for the first time in this study. The compound showed scavenge activities in ORAC and DPPH radicals with the values of 0.83 ± 0.01 and 84.66 ± 0.75% (at the concentration of 500 ppm), respectively. It also inhibited production of NO for RAW 264.7 stimulated by LPS and protected oxidative stress induced by glutamate in HT22-immortalized hippocampal. The IC on inhibition of NO production and EC value on protective efficacy of oxidative stress were 78.72 ± 1.43 lM and 176.25 ± 7.23 lM, respectively. These results demonstrate that the phenylethanoid glycoside might be useful as a neu- roprotective agent because of their antioxidant, anti-inflammatory, and neuroprotective effects. Keywords 8 -(3,4-Dihydroxyphenyl)ethyl-O-a-L-rhamnopyranosyl-(1 ? 4)-2-O-(E)-caffeoyl-a-L-arabinopyranoside Anti-inflammation  Antioxidation  NO production 1 Introduction derived therefrom (Newman and Cragg 2007; Orhan 2012). Especially, pharmacological active materials derived from Even though most drugs currently commercially used in botanical galenicals have

Journal

Brazilian Journal of BotanySpringer Journals

Published: May 29, 2018

References

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