A repeated column chromatography for Forsythia koreana Nakai. ﬂowers afforded a phenylethane glycoside, which was identiﬁed as 8 -(3,4-dihydroxyphenyl)ethyl-O-a-L-rhamnopyranosyl-(1 ? 4)-2-O-(E)-caffeoyl-a-L-arabinopyranoside 1 13 based on spectroscopic analyses of 1D NMR ( H-NMR, C-NMR, DEPT), 2D NMR (gCOSY, gHSQC, gHMBC), FAB/ MS, speciﬁc rotation, and IR spectrometry. This compound was isolated from F. koreana ﬂower for the ﬁrst time in this study. The compound showed scavenge activities in ORAC and DPPH radicals with the values of 0.83 ± 0.01 and 84.66 ± 0.75% (at the concentration of 500 ppm), respectively. It also inhibited production of NO for RAW 264.7 stimulated by LPS and protected oxidative stress induced by glutamate in HT22-immortalized hippocampal. The IC on inhibition of NO production and EC value on protective efﬁcacy of oxidative stress were 78.72 ± 1.43 lM and 176.25 ± 7.23 lM, respectively. These results demonstrate that the phenylethanoid glycoside might be useful as a neu- roprotective agent because of their antioxidant, anti-inﬂammatory, and neuroprotective effects. Keywords 8 -(3,4-Dihydroxyphenyl)ethyl-O-a-L-rhamnopyranosyl-(1 ? 4)-2-O-(E)-caffeoyl-a-L-arabinopyranoside Anti-inﬂammation Antioxidation NO production 1 Introduction derived therefrom (Newman and Cragg 2007; Orhan 2012). Especially, pharmacological active materials derived from Even though most drugs currently commercially used in botanical galenicals have
Brazilian Journal of Botany – Springer Journals
Published: May 29, 2018
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