Phenotypic Expression of the Mutant Gene diabetes insipidus in Rats and Criteria of Genotyping by Phenotype

Phenotypic Expression of the Mutant Gene diabetes insipidus in Rats and Criteria of Genotyping by... The autosomal semidominant mutant gene di(diabetes insipidus) is manifested in homozygotes in the form of diabetes insipidus with water consumption from 25 to 100% of body weight per day. The heterozygotesdi/+ drink water at a rate higher than 5% but lower than 25%. The level of water consumption in rats with +/+ genotype does not exceed 5% of body weight per day. Segregation analysis of F1 animals yielded by various crosses showed that genotyping of di/di homozygotes is absolutely reliable at 30% and higher level of the water consumption per day. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Russian Journal of Genetics Springer Journals

Phenotypic Expression of the Mutant Gene diabetes insipidus in Rats and Criteria of Genotyping by Phenotype

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Publisher
Springer Journals
Copyright
Copyright © 2003 by MAIK “Nauka/Interperiodica”
Subject
Biomedicine; Human Genetics
ISSN
1022-7954
eISSN
1608-3369
D.O.I.
10.1023/A:1022022927757
Publisher site
See Article on Publisher Site

Abstract

The autosomal semidominant mutant gene di(diabetes insipidus) is manifested in homozygotes in the form of diabetes insipidus with water consumption from 25 to 100% of body weight per day. The heterozygotesdi/+ drink water at a rate higher than 5% but lower than 25%. The level of water consumption in rats with +/+ genotype does not exceed 5% of body weight per day. Segregation analysis of F1 animals yielded by various crosses showed that genotyping of di/di homozygotes is absolutely reliable at 30% and higher level of the water consumption per day.

Journal

Russian Journal of GeneticsSpringer Journals

Published: Oct 7, 2004

References

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