Phase III trial comparing UFT+PSK to UFT+LV in stage IIB, III colorectal cancer (MCSGO-CCTG)

Phase III trial comparing UFT+PSK to UFT+LV in stage IIB, III colorectal cancer (MCSGO-CCTG) Surg Today (2018) 48:66–72 ORIGINAL ARTICLE Phase III trial comparing UFT + PSK to UFT + LV in stage IIB, III colorectal cancer (MCSGO‑CCTG) 1 2 3 4 5 2 Yasuhiro Miyake · Junichi Nishimura · Takeshi Kato · Masataka Ikeda · Masaki Tsujie · Taishi Hata · 2 2 2 4 1 Ichiro Takemasa · Tsunekazu Mizushima · Hirofumi Yamamoto · Mitsugu Sekimoto · Riichiro Nezu · 2 2 Yuichiro Doki · Masaki Mori · Multi‑ center Clinical Study Group of Osaka, Colorectal Cancer Treatment Group (MCSGO) Received: 21 December 2016 / Accepted: 22 May 2017 / Published online: 20 June 2017 © Springer Japan KK 2017 Abstract or UFT/LV (n = 179) (median age 65 years, colon/ Purpose Oral adjuvant uracil and tegafur plus leucovorin rectum 67.4/32.6%, stage IIB/IIIA/IIIB/IIIC (UFT/LV) is not inferior to standard weekly fluorouracil 11.1/15.7/55.0/18.2%). The 3-year DFS rate was 82.3% and folinate for stage II/III colon cancer. However, protein- in those receiving UFT/LV and 72.1% in those receiv- bound polysaccharide K (PSK) has been evaluated as post- ing UFT/PSK. The non-inferiority of UFT/PSK adjuvant operative adjuvant therapy for colorectal cancer. This report therapy to UFT/LV therapy was not verified ( −9.06%, 90% Surgery Today Springer Journals

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Copyright © 2017 by Springer Japan KK
Medicine & Public Health; Surgery; Surgical Oncology
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