Support Care Cancer (2018) 26:1273–1279 https://doi.org/10.1007/s00520-017-3950-y ORIGINAL ARTICLE Phase II open label pilot trial of aprepitant and palonosetron for the prevention of chemotherapy-induced nausea and vomiting (CINV) in patients receiving moderately emetogenic FOLFOX chemotherapy for the treatment of colorectal cancer 1 2 3 4 Joseph S. Bubalo & Jon D. Herrington & Marc Takemoto & Patricia Willman & 5 6 7 1 7 Michael S. Edwards & Casey Williams & Alan Fisher & Alison Palumbo & Eric Chen & 1 1 Charles Blanke & Charles D. Lopez Received: 10 May 2017 /Accepted: 25 October 2017 /Published online: 31 October 2017 Springer-Verlag GmbH Germany 2017 Abstract orally on day 1 and 80 mg on days 2 and 3. Palonosetron Purpose Chemotherapy-induced nausea and vomiting 0.25 mg was given IV push on day 1 only. Dexamethasone (CINV) causes significant morbidity among colorectal cancer 12 mg was administered orally on day 1 and 8 mg each morn- patients, receiving fluorouracil, oxaliplatin, and leucovorin ing on days 2 through 4. Assessments including emetic events, (FOLFOX) chemotherapy even with standard antiemetic pro- rescue doses, nutritional intake, and appetite were recorded in phylaxis. The purpose of this study is to determine if the a patient
Supportive Care in Cancer – Springer Journals
Published: Oct 31, 2017
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