Pharmacological Interventions for Obesity: Current and Future Targets

Pharmacological Interventions for Obesity: Current and Future Targets Purpose of Review Obesity in the USA has been on a constant rise since the Center for Disease Control and Prevention (CDC) began tracking it over 50 years ago. Despite focused attention on this epidemic, pharmacological treatments aimed at obesity are lacking. Here, we briefly give perspective on the central and peripheral mechanisms underlying feeding behaviors and describe the existing pharmacological treatments for obesity. With this lens, I suggest future targets for the treatment of obesity. Recent Findings Given the development of genetic and molecular tools, understanding of how energy expenditure is modulated is becoming more nuanced. There is growing evidence for a link between obesity and addiction, which should be utilized in the development of new pharmacological treatments. Summary More focus is needed on identifying targets for anti-obesity pharmacology. In doing so, research should include intensive investigation of the brain’sreward circuitry. . . . Keywords Obesity Pharmacology Addiction Dopamine Introduction burden, obesity has taken center stage as a national health concern. However, despite focused efforts, obesity rates In the USA, rates of obesity have nearly tripled since the remain unaffected in the USA [1]. Center for Disease Control and Prevention (CDC) first Historically, obesity has been considered a http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Addiction Reports Springer Journals

Pharmacological Interventions for Obesity: Current and Future Targets

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Publisher
Springer Journals
Copyright
Copyright © 2018 by Springer International Publishing AG, part of Springer Nature
Subject
Medicine & Public Health; Psychiatry; Neurology
eISSN
2196-2952
D.O.I.
10.1007/s40429-018-0204-0
Publisher site
See Article on Publisher Site

Abstract

Purpose of Review Obesity in the USA has been on a constant rise since the Center for Disease Control and Prevention (CDC) began tracking it over 50 years ago. Despite focused attention on this epidemic, pharmacological treatments aimed at obesity are lacking. Here, we briefly give perspective on the central and peripheral mechanisms underlying feeding behaviors and describe the existing pharmacological treatments for obesity. With this lens, I suggest future targets for the treatment of obesity. Recent Findings Given the development of genetic and molecular tools, understanding of how energy expenditure is modulated is becoming more nuanced. There is growing evidence for a link between obesity and addiction, which should be utilized in the development of new pharmacological treatments. Summary More focus is needed on identifying targets for anti-obesity pharmacology. In doing so, research should include intensive investigation of the brain’sreward circuitry. . . . Keywords Obesity Pharmacology Addiction Dopamine Introduction burden, obesity has taken center stage as a national health concern. However, despite focused efforts, obesity rates In the USA, rates of obesity have nearly tripled since the remain unaffected in the USA [1]. Center for Disease Control and Prevention (CDC) first Historically, obesity has been considered a

Journal

Current Addiction ReportsSpringer Journals

Published: May 7, 2018

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