Clin Drug Investig (2017) 37:885–887 DOI 10.1007/s40261-017-0539-7 COMMENTARY Pharmacokinetic Properties of Fast-acting Insulin Aspart Administered in Different Subcutaneous Injection Regions: Response to the commentary by Nuggehally R. Srinivas 1 1 1 1 • • • • Tim Heise Ulrike Ho¨velmann Leszek Nosek Bettina Sassenfeld 2 3 Karen Margrete Due Thomsen Hanne Haahr Published online: 8 June 2017 Springer International Publishing Switzerland 2017 We are grateful to Dr. Srinivas for his thorough review of the validity of pharmacodynamic data in healthy people, our data. He points out potential differences in the phar- the results of a slower and slightly blunted insulin macodynamic effects of insulin preparations between absorption with injection in the thigh compared with healthy people and people with diabetes and discusses abdominal injections is consistent with published data of several reasons for these differences, including insulin other insulins in both healthy people and patients with type dose, effect of endogenous insulin, anti-insulin antibodies, 1 diabetes. Dr. Srinivas cited our study investigating the and local injection site issues in people with diabetes . pharmacokinetic/pharmacodynamic effects of insulin Indeed, there have been some discussions about the degludec when injected into different regions  and the validity of pharmacodynamic results with
Clinical Drug Investigation – Springer Journals
Published: Jun 8, 2017
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