Clin Drug Investig (2017) 37:881–884 DOI 10.1007/s40261-017-0538-8 COMMENTARY Pharmacodynamics of Insulin Preparations Administered in Different Subcutaneous Injection Sites: Are There Differences Between Healthy Subjects Versus Diabetic Patients? Nuggehally R. Srinivas Published online: 8 June 2017 Springer International Publishing Switzerland 2017 1 Background injection sites; and (3) provide some perspectives on the above ﬁndings with respect to pharmacokinetic and phar- Hovelmann et al.  have diligently examined the phar- macodynamic data from other insulin preparations in dia- macokinetics of a fast-acting insulin formulation (Aspart) betic patients relative to healthy subjects. in healthy human volunteers following subcutaneous (SC) administration to three different sites, namely: abdomen, upper arm and thigh . From a pharmacokinetic per- 3 Context spective, it appeared that abdomen and upper arm produced relatively higher exposure of insulin at early time points; 3.1 Fast-Acting Insulin however, it was recommended that Aspart could be administered at any SC injection site suggesting that from a In study of Hovelmann et al. , if one examined the mean pharmacodynamic perspective all injection sites of Aspart pharmacokinetic proﬁle of insulin obtained from three dose would have behaved similarly. Although the focus of different sites, it was apparent that the absorption phases the investigation
Clinical Drug Investigation – Springer Journals
Published: Jun 8, 2017
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