Psychopharmacology (2017) 234:2643–2655 DOI 10.1007/s00213-017-4665-y ORIGINAL INVESTIGATION Pharmacodynamic and pharmacokinetic assessment of electronic cigarettes, combustible cigarettes, and nicotine gum: implications for abuse liability 1 1 2 1 Mitchell F. Stiles & Leanne R. Campbell & Donald W. Graff & Bobbette A. Jones & 3 3 Reginald V. Fant & Jack E. Henningfield Received: 21 March 2017 /Accepted: 19 May 2017 /Published online: 20 June 2017 The Author(s) 2017. This article is an open access publication Abstract more rapid initial uptake of nicotine compared to nicotine Rationale Electronic cigarettes (ECs) are becoming popular gum, but peak concentration and long-term extent of uptake alternatives for smokers, but there has been limited study of were not different or were lower with Vuse. their abuse liability. Conclusions Collectively, these findings suggest that Vuse Objectives The objective of this study was to evaluate the Solo likely has an abuse liability that is somewhat greater than abuse liability of three Vuse Solo ECs, ranging from 14 to nicotine gum but lower than cigarettes. 36 mg in nicotine content, relative to high- and low-abuse Trial registration ClinicalTrials.gov identifier: liability comparator products (usual brand combustible ciga- NCT02269514 rettes and nicotine gum, respectively) in a group of 45
Psychopharmacology – Springer Journals
Published: Jun 20, 2017
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
All the latest content is available, no embargo periods.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud