Pharmacodynamic and pharmacokinetic assessment of electronic cigarettes, combustible cigarettes, and nicotine gum: implications for abuse liability

Pharmacodynamic and pharmacokinetic assessment of electronic cigarettes, combustible cigarettes,... Psychopharmacology (2017) 234:2643–2655 DOI 10.1007/s00213-017-4665-y ORIGINAL INVESTIGATION Pharmacodynamic and pharmacokinetic assessment of electronic cigarettes, combustible cigarettes, and nicotine gum: implications for abuse liability 1 1 2 1 Mitchell F. Stiles & Leanne R. Campbell & Donald W. Graff & Bobbette A. Jones & 3 3 Reginald V. Fant & Jack E. Henningfield Received: 21 March 2017 /Accepted: 19 May 2017 /Published online: 20 June 2017 The Author(s) 2017. This article is an open access publication Abstract more rapid initial uptake of nicotine compared to nicotine Rationale Electronic cigarettes (ECs) are becoming popular gum, but peak concentration and long-term extent of uptake alternatives for smokers, but there has been limited study of were not different or were lower with Vuse. their abuse liability. Conclusions Collectively, these findings suggest that Vuse Objectives The objective of this study was to evaluate the Solo likely has an abuse liability that is somewhat greater than abuse liability of three Vuse Solo ECs, ranging from 14 to nicotine gum but lower than cigarettes. 36 mg in nicotine content, relative to high- and low-abuse Trial registration ClinicalTrials.gov identifier: liability comparator products (usual brand combustible ciga- NCT02269514 rettes and nicotine gum, respectively) in a group of 45 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Psychopharmacology Springer Journals

Pharmacodynamic and pharmacokinetic assessment of electronic cigarettes, combustible cigarettes, and nicotine gum: implications for abuse liability

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Publisher
Springer Berlin Heidelberg
Copyright
Copyright © 2017 by The Author(s)
Subject
Biomedicine; Neurosciences; Pharmacology/Toxicology; Psychiatry
ISSN
0033-3158
eISSN
1432-2072
D.O.I.
10.1007/s00213-017-4665-y
Publisher site
See Article on Publisher Site

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