pH-sensitive hydrogels for colon specific delivery

pH-sensitive hydrogels for colon specific delivery A novel fluid loss additive (FLA) was synthesized using 2-acrylamido-2-methyl-propane sulphonic acid, acrylic acid, N,N-dimethyl acrylamide and N-vinyl-2-pyrrolidone by aqueous solution polymerization. TGA spectrum indicated that the decomposition temperature of FLA was higher than 330°C. The fluid loss testing showed that the FLA had an outstanding property of reducing fluid loss at 203°C in salt water cement slurry and the amount of fluid loss was controlled about 100 mL when FLA dosage was 1.0%. Cement slurry with 0.1–1.5% FLA kept stable thickening time. A better performance of FLA was found in fresh water cement slurry than in salt water cement slurry. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Russian Journal of Applied Chemistry Springer Journals

pH-sensitive hydrogels for colon specific delivery

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Publisher
Pleiades Publishing
Copyright
Copyright © 2014 by Pleiades Publishing, Ltd.
Subject
Chemistry; Chemistry/Food Science, general; Industrial Chemistry/Chemical Engineering
ISSN
1070-4272
eISSN
1608-3296
D.O.I.
10.1134/S107042721409033X
Publisher site
See Article on Publisher Site

Abstract

A novel fluid loss additive (FLA) was synthesized using 2-acrylamido-2-methyl-propane sulphonic acid, acrylic acid, N,N-dimethyl acrylamide and N-vinyl-2-pyrrolidone by aqueous solution polymerization. TGA spectrum indicated that the decomposition temperature of FLA was higher than 330°C. The fluid loss testing showed that the FLA had an outstanding property of reducing fluid loss at 203°C in salt water cement slurry and the amount of fluid loss was controlled about 100 mL when FLA dosage was 1.0%. Cement slurry with 0.1–1.5% FLA kept stable thickening time. A better performance of FLA was found in fresh water cement slurry than in salt water cement slurry.

Journal

Russian Journal of Applied ChemistrySpringer Journals

Published: Dec 30, 2014

References

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