pH-dependent aggregation and secretion of soluble monomeric influenza hemagglutinin

pH-dependent aggregation and secretion of soluble monomeric influenza hemagglutinin We previously reported the expression of soluble A/Victoria/3/75 (H3N2) hemagglutinin in insect cells and the molecular and immunological structure of an aggregated fraction, only observed in cell supernatant when expression was performed at low pH (23). Here we report that besides this aggregated a monomeric and possibly a trimeric structure is detected in cell supernatant, irrespective of the pH of the medium. Evidence is presented that the aggregated fraction is generated out of monomeric HA0s molecules due to a low intracellular pH encountered during secretion. Archives of Virology Springer Journals

pH-dependent aggregation and secretion of soluble monomeric influenza hemagglutinin

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