Persistent Skin Pouches Following Subcutaneous Immunoglobulin Infusions in a Girl with Immunodeficiency, Bullous Skin Lesions and Melanosis Oculi

Persistent Skin Pouches Following Subcutaneous Immunoglobulin Infusions in a Girl with... J Clin Immunol (2017) 37:505–507 DOI 10.1007/s10875-017-0411-9 LETTER TO EDITOR Persistent Skin Pouches Following Subcutaneous Immunoglobulin Infusions in a Girl with Immunodeficiency, Bullous Skin Lesions and Melanosis Oculi 1,2 1 3 4 Renate Krüger & Cornelia Feiterna-Sperling & Ulrike Blume-Peytavi & Birgit Lala & 1,5,6,7 1 Horst von Bernuth & Volker Wahn Received: 25 November 2016 /Accepted: 7 June 2017 /Published online: 17 June 2017 Springer Science+Business Media, LLC 2017 Keywords S.C. Immunoglobulin Treatment adverse Patient History The girl was born to consanguineous Turkish effects inflammation parents (first degree cousins) after an uncomplicated pregnan- cy. Both parents, an older sister and brother were healthy. No other family members showed signs of skin disease or immu- To the Editor nodeficiency. The clinical findings of the patient were as Subcutaneous (s.c.) IgG replacement (SCIG) was introduced follows: in 1952 and is now frequently applied in patients with humoral Skin: The girl developed bullous skin lesions within the immunodeficiency (reviewed in [1]). Systemic adverse events first days of life, recurrent bullae appeared on extremities are rare, cutaneous side effects (swelling, redness) are com- and the trunk in the first years of life (Fig. 1 a) and mainly mon but mostly mild and http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Clinical Immunology Springer Journals

Persistent Skin Pouches Following Subcutaneous Immunoglobulin Infusions in a Girl with Immunodeficiency, Bullous Skin Lesions and Melanosis Oculi

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Publisher
Springer US
Copyright
Copyright © 2017 by Springer Science+Business Media, LLC
Subject
Biomedicine; Immunology; Infectious Diseases; Internal Medicine; Medical Microbiology
ISSN
0271-9142
eISSN
1573-2592
D.O.I.
10.1007/s10875-017-0411-9
Publisher site
See Article on Publisher Site

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