Neurol Sci (2017) 38:1523–1524 DOI 10.1007/s10072-017-2958-x LETTER TO THE EDITOR Persistence of anti-NMDAR antibodies in CSF after recovery from autoimmune encephalitis 1 2 1 1 1 S. Mariotto & F. Andreetta & A. Farinazzo & S. Monaco & S. Ferrari Received: 16 December 2016 /Accepted: 6 April 2017 /Published online: 6 May 2017 Springer-Verlag Italia 2017 Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis activity. Blood tests noted only a severe hyponatremia and the is characterized by psychiatric and neuropsychiatric manifes- presence of low titer anti-thyroid peroxidase and thyroglobu- tations preceded by prodromal symptoms in about 70% of lin antibodies. CSF analysis showed lymphocytic pleocytosis patients. It can occur as an autoimmune antibody-mediated (360 cells/μL with 98% lymphocytes); extensive viral PCR and cultures ruled out an infectious etiology. She was treated non-paraneoplastic syndrome or as a paraneoplastic disorder, triggered by different tumors, more often an ovarian teratoma. with acyclovir and intravenous corticosteroids with a progres- NMDARs are localized in neuronal post-synaptic membranes sive tapering. At the end of February, CSF analysis revealed and play a role in synaptic transmission and plasticity. In vitro the presence of anti-NMDAR antibodies that were absent in and in vivo investigations confirm that anti-NMDAR antibod- serum. The patient
Neurological Sciences – Springer Journals
Published: May 6, 2017
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