Peritoneal and pleural fluids may appear hyperintense on hepatobiliary phase using hepatobiliary MR contrast agents

Peritoneal and pleural fluids may appear hyperintense on hepatobiliary phase using hepatobiliary... Aim To describe the effect of hepatobiliary-specific MR imaging contrast agent (HBCA) administration on the signal intensity of peritoneal and pleural fluid effusions on T1-weighted MR images. Materials and methods From October 2015 to May 2016 139 patients (mean 60±10 years old, 69 % males) with peritoneal or pleural effusions without biliary leakage who underwent HBCA-MRI (Gd-BOPTA or Gd-EOB-DTPA) at 1.5T and 3T were included from two centres. The fluid signal intensity was classified as hypo/iso/hyperintense before/after HBCA administration. The relative signal enhancement (RE) was calculated. Results On hepatobiliary phase (HBP), peritoneal fluids appeared hyper/isointense in 88–100 % and pleural effusions in 100 % of the patients following Gd-BOPTA administration. All fluids remained hypointense following Gd-EOB-DTPA. The signal intensity of fluids increased with both HBCA but RE was significantly higher following Gd-BOPTA (p=0.002 to <0.001). RE was correlated with HBP acquisition time-point (r=0.42, p<0.001 and r=0.50, p=0.033 for peritoneal and pleural fluids). Conclusion The signal intensity of pleural and peritoneal fluids progressively increases following HBCA administration in the absence of biliary leakage. Due to its later hepatobiliary phase, this is more pronounced after Gd-BOPTA injection, leading to fluid hyperintensity that is not observed after Gd-EOB-DTPA injection. Key Points � http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png European Radiology Springer Journals

Peritoneal and pleural fluids may appear hyperintense on hepatobiliary phase using hepatobiliary MR contrast agents

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Publisher
Springer Journals
Copyright
Copyright © 2018 by European Society of Radiology
Subject
Medicine & Public Health; Imaging / Radiology; Diagnostic Radiology; Interventional Radiology; Neuroradiology; Ultrasound; Internal Medicine
ISSN
0938-7994
eISSN
1432-1084
DOI
10.1007/s00330-017-5261-6
pmid
29374320
Publisher site
See Article on Publisher Site

Abstract

Aim To describe the effect of hepatobiliary-specific MR imaging contrast agent (HBCA) administration on the signal intensity of peritoneal and pleural fluid effusions on T1-weighted MR images. Materials and methods From October 2015 to May 2016 139 patients (mean 60±10 years old, 69 % males) with peritoneal or pleural effusions without biliary leakage who underwent HBCA-MRI (Gd-BOPTA or Gd-EOB-DTPA) at 1.5T and 3T were included from two centres. The fluid signal intensity was classified as hypo/iso/hyperintense before/after HBCA administration. The relative signal enhancement (RE) was calculated. Results On hepatobiliary phase (HBP), peritoneal fluids appeared hyper/isointense in 88–100 % and pleural effusions in 100 % of the patients following Gd-BOPTA administration. All fluids remained hypointense following Gd-EOB-DTPA. The signal intensity of fluids increased with both HBCA but RE was significantly higher following Gd-BOPTA (p=0.002 to <0.001). RE was correlated with HBP acquisition time-point (r=0.42, p<0.001 and r=0.50, p=0.033 for peritoneal and pleural fluids). Conclusion The signal intensity of pleural and peritoneal fluids progressively increases following HBCA administration in the absence of biliary leakage. Due to its later hepatobiliary phase, this is more pronounced after Gd-BOPTA injection, leading to fluid hyperintensity that is not observed after Gd-EOB-DTPA injection. Key Points �

Journal

European Radiology – Springer Journals

Published: Jan 26, 2018

References

  • Molecular determinants in the transport of a bile acid-derived diagnostic agent in tumoral and nontumoral cell lines of human liver
    Libra, A; Fernetti, C; Lorusso, V
  • Hepatocellular carcinoma in a North American population: does hepatobiliary MR imaging with Gd-EOB-DTPA improve sensitivity and confidence for diagnosis?
    Bashir, MR; Gupta, RT; Davenport, MS
  • Current evidence for the diagnostic value of gadoxetic acid-enhanced magnetic resonance imaging for liver metastasis
    Tsurusaki, M; Sofue, K; Murakami, T
  • Focal Nodular Hyperplasia and Hepatocellular Adenoma: Accuracy of Gadoxetic Acid-enhanced MR Imaging--A Systematic Review
    McInnes, MD; Hibbert, RM; Inacio, JR
  • Hepatobiliary MR imaging with gadolinium-based contrast agents
    Frydrychowicz, A; Lubner, MG; Brown, JJ
  • Biliary MR imaging with Gd-EOB- DTPA and its clinical applications
    Lee, NK; Kim, S; Lee, JW; Lee, SH
  • Biliary Anastomotic Leakage following Orthotopic Liver Transplant: The Use of Primovist (Gadoxetate Disodium) as an Intravenous MR Cholangiography Contrast Agent for Biliary Leakage
    Blair, PS; Low, G
  • Advantages of gadobenate dimeglumine-enhanced MR cholangiography in the diagnosis of post-liver transplant bile leakage
    Fontarensky, M; Montoriol, PF; Buc, E
  • Delayed contrast enhancement of ascitic fluid on CT: frequency and significance
    Cooper, C; Silverman, PM; Davros, WJ
  • Opacification of ascitic fluid on delayed contrast computed tomography scans
    Hammerman, AM; Oberle, PA; Susman, N
  • Delayed enhancement of ascites following high-dose contrast CT for liver metastases
    Minutoli, A; Volta, S; Gaeta, M
  • Delayed enhancement of ascites after i.v. contrast material administration at CT: time course and clinical correlation
    Benedetti, N; Aslam, R; Wang, ZJ
  • Enhancing ascites: an aid to CT diagnosis
    Wise, SW; DeMeo, JH; Austin, RF
  • Enhancement of ascites during abdominal oncological endovascular intervention without iatrogenic extravasation in patients with chronic liver disease
    Araki, T; Okada, H; Araki, T
  • ESGAR consensus statement on liver MR imaging and clinical use of liver-specific contrast agents
    Neri, E; Bali, MA; Ba-Ssalamah, A
  • The ultrastructural basis of capillary permeability studies with peroxides as a tracer
    Karnovsky, MJ
  • Diffusional transport of solites through mes- entery and peritoneum
    Gosselin, RE; Berndt, WO
  • Pathways of fluid transport and reabsorption across the peritoneal membrane
    Asghar, RB; Davies, SJ
  • Drainage of radiographic contrast media from the abdominal cavity. Experimental studies in rats
    Lindgren, I; Nagy, EJ; Virtama, P
  • Clinical applications of gadobenate dimeglumine-enhanced magnetic resonance cholangiography: an expanded pictorial review
    Turkbey, B; Akpinar, E; Balli, O
  • Biliary complications after orthotopic liver transplantation: A review of incidence and risk factors
    Gastaca, M
  • Early phase detection of bile leak after hepatobiliary surgery: Value of Gd-EOB-DTPA-enhanced MR cholangiography
    Alegre Castellanos, A; Molina Granados, JF; Escribano Fernandez, J
  • Gadoxetate disodium-enhanced magnetic resonance cholangiog-raphy for the noninvasive detection of an active bile duct leak after laparoscopic cholecystectomy
    Marin, D; Bova, V; Agnello, F; Youngblood, R; Midiri, M; Brancatelli, G
  • Non-invasive detection of biliary leaks using Gd-EOB-DTPA- enhanced MR cholangiography: comparison with T2-weighted MR cholangiography
    Kantarcı, M; Pirimoglu, B; Karabulut, N
  • Bile duct leaks after laparoscopic cholecystectomy: value of contrast-enhanced MRCP
    Aduna, M; Larena, JA; Martin, D

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