Peripheral nerve regeneration: autologous conduit of vein plus perineurium

Peripheral nerve regeneration: autologous conduit of vein plus perineurium A new method to enhance peripheral nerve regeneration is described. A 2-cm-long segment of right sciatic nerve of 90 Sprague-Dawley rats was transected and the gap was then bridged using one of the three methods: group 1 (treated, n 1 = 30), a 2-cm-long strip of perineurium inserted inside a 2-cm-long vein graft; group 2 (control, n 2 = 30), a vein graft alone; group 3 (standard nerve graft, n 3 = 30), a resected segment of the sciatic nerve. Clinical and electrophysiological tests and quantitative analysis carried out 12 weeks after surgical procedure showed a good nerve regeneration for the treated and the control vein group, although it was lower than the standard nerve graft group. G factor values, index of nervous myelinization, were not significantly different between groups 1 and 3 ( P < 0.05), but either were significantly lower than that of group 2. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png European Journal of Plastic Surgery Springer Journals

Peripheral nerve regeneration: autologous conduit of vein plus perineurium

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Publisher
Springer-Verlag
Copyright
Copyright © 2009 by Springer-Verlag
Subject
Medicine & Public Health; Plastic Surgery
ISSN
0930-343X
eISSN
1435-0130
D.O.I.
10.1007/s00238-008-0302-7
Publisher site
See Article on Publisher Site

Abstract

A new method to enhance peripheral nerve regeneration is described. A 2-cm-long segment of right sciatic nerve of 90 Sprague-Dawley rats was transected and the gap was then bridged using one of the three methods: group 1 (treated, n 1 = 30), a 2-cm-long strip of perineurium inserted inside a 2-cm-long vein graft; group 2 (control, n 2 = 30), a vein graft alone; group 3 (standard nerve graft, n 3 = 30), a resected segment of the sciatic nerve. Clinical and electrophysiological tests and quantitative analysis carried out 12 weeks after surgical procedure showed a good nerve regeneration for the treated and the control vein group, although it was lower than the standard nerve graft group. G factor values, index of nervous myelinization, were not significantly different between groups 1 and 3 ( P < 0.05), but either were significantly lower than that of group 2.

Journal

European Journal of Plastic SurgerySpringer Journals

Published: Feb 1, 2009

References

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