Peripheral endocannabinoid concentrations are not associated with verbal memory impairment during MDMA intoxication

Peripheral endocannabinoid concentrations are not associated with verbal memory impairment during... Psychopharmacology (2018) 235:709–717 https://doi.org/10.1007/s00213-017-4787-2 ORIGINAL INVESTIGATION Peripheral endocannabinoid concentrations are not associated with verbal memory impairment during MDMA intoxication 1 2,3,4 2,5,6 2,5 2,6 2,3 E. Haijen & M. Farre & R. de la Torre & A. Pastor & E. Olesti & N. Pizarro & 1 1 J. G. Ramaekers & K. P. C. Kuypers Received: 29 May 2017 /Accepted: 7 November 2017 /Published online: 16 November 2017 The Author(s) 2017. This article is an open access publication Abstract baseline, before (90 min post-treatment) and after cognitive tests Background Preclinical data have suggested involvement of the (150 min post-treatment). endocannabinoid (eCB) system in MDMA-induced memory im- Results Findings showed that MDMA impaired memory pairment. Clinical research has shown that blockade of the 5-HT 90 min post-treatment in the word learning task. This effect receptor nulls memory impairment during MDMA intoxication. was a replication of previous studies using the same dose of Interestingly, studies have demonstrated that the eCB and the 5- MDMA (75 mg) and the same learning paradigm. Contrary to HT system interact. It was hypothesized that MDMA would our hypothesis, MDMA did not affect eCB concentrations, cause an increase in eCB concentrations together with a decrease nor http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Psychopharmacology Springer Journals

Peripheral endocannabinoid concentrations are not associated with verbal memory impairment during MDMA intoxication

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Publisher
Springer Berlin Heidelberg
Copyright
Copyright © 2017 by The Author(s)
Subject
Biomedicine; Neurosciences; Pharmacology/Toxicology; Psychiatry
ISSN
0033-3158
eISSN
1432-2072
D.O.I.
10.1007/s00213-017-4787-2
Publisher site
See Article on Publisher Site

Abstract

Psychopharmacology (2018) 235:709–717 https://doi.org/10.1007/s00213-017-4787-2 ORIGINAL INVESTIGATION Peripheral endocannabinoid concentrations are not associated with verbal memory impairment during MDMA intoxication 1 2,3,4 2,5,6 2,5 2,6 2,3 E. Haijen & M. Farre & R. de la Torre & A. Pastor & E. Olesti & N. Pizarro & 1 1 J. G. Ramaekers & K. P. C. Kuypers Received: 29 May 2017 /Accepted: 7 November 2017 /Published online: 16 November 2017 The Author(s) 2017. This article is an open access publication Abstract baseline, before (90 min post-treatment) and after cognitive tests Background Preclinical data have suggested involvement of the (150 min post-treatment). endocannabinoid (eCB) system in MDMA-induced memory im- Results Findings showed that MDMA impaired memory pairment. Clinical research has shown that blockade of the 5-HT 90 min post-treatment in the word learning task. This effect receptor nulls memory impairment during MDMA intoxication. was a replication of previous studies using the same dose of Interestingly, studies have demonstrated that the eCB and the 5- MDMA (75 mg) and the same learning paradigm. Contrary to HT system interact. It was hypothesized that MDMA would our hypothesis, MDMA did not affect eCB concentrations, cause an increase in eCB concentrations together with a decrease nor

Journal

PsychopharmacologySpringer Journals

Published: Nov 16, 2017

References

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