Psychopharmacology (2018) 235:709–717 https://doi.org/10.1007/s00213-017-4787-2 ORIGINAL INVESTIGATION Peripheral endocannabinoid concentrations are not associated with verbal memory impairment during MDMA intoxication 1 2,3,4 2,5,6 2,5 2,6 2,3 E. Haijen & M. Farre & R. de la Torre & A. Pastor & E. Olesti & N. Pizarro & 1 1 J. G. Ramaekers & K. P. C. Kuypers Received: 29 May 2017 /Accepted: 7 November 2017 /Published online: 16 November 2017 The Author(s) 2017. This article is an open access publication Abstract baseline, before (90 min post-treatment) and after cognitive tests Background Preclinical data have suggested involvement of the (150 min post-treatment). endocannabinoid (eCB) system in MDMA-induced memory im- Results Findings showed that MDMA impaired memory pairment. Clinical research has shown that blockade of the 5-HT 90 min post-treatment in the word learning task. This effect receptor nulls memory impairment during MDMA intoxication. was a replication of previous studies using the same dose of Interestingly, studies have demonstrated that the eCB and the 5- MDMA (75 mg) and the same learning paradigm. Contrary to HT system interact. It was hypothesized that MDMA would our hypothesis, MDMA did not affect eCB concentrations, cause an increase in eCB concentrations together with a decrease nor
Psychopharmacology – Springer Journals
Published: Nov 16, 2017
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