Clin Drug Investig (2018) 38:673–693 https://doi.org/10.1007/s40261-018-0662-0 SYSTEMATIC REVIEW Peri-operative Medication Dosing in Adult Obese Elective Surgical Patients: A Systematic Review of Clinical Studies 1 1 1 1 • • • Zahid Hussain Colin Curtain Corinne Mirkazemi Syed Tabish Razi Zaidi Published online: 1 June 2018 Springer International Publishing AG, part of Springer Nature 2018 Abstract recommendations was observed for various medications. Lean Background Despite the increasing numbers of obese body weight was proposed as a suitable weight scalar for patients undergoing elective surgery, there is a lack of induction of anaesthesia with propofol whereas total body evidence-based dosing guidelines for peri-operative medi- weight for maintenance of anaesthesia with propofol and cations in obesity. depolarizing muscle relaxants. Ideal body weight was reported Objective The objective was to systematically review the as an appropriate dosing scalar for non-depolarizing muscle dosing and outcomes of peri-operative medications used in relaxants and neuromuscular reversal agents. Both corrected obese elective surgical patients. body weight 40% and ideal body weight were reported as Methods Medical subject headings and general keywords suitable weight scalars for post-operative analgesia with mor- were used to systematically search multiple databases phine. The standard 2-g dose of cefazolin appeared effective in (PubMed,
Clinical Drug Investigation – Springer Journals
Published: Jun 1, 2018
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