Arch Gynecol Obstet (2017) 296:435–444 DOI 10.1007/s00404-017-4448-z REVIEW ‘‘Per vaginam’’ topical use of hormonal drugs in women with symptomatic deep endometriosis: a narrative literature review 1 1 1 1 • • • • Laura Buggio Caterina Lazzari Ermelinda Monti Giussy Barbara 1 1 Nicola Berlanda Paolo Vercellini Received: 21 February 2017 / Accepted: 26 June 2017 / Published online: 29 June 2017 Springer-Verlag GmbH Germany 2017 Abstract dimensions measured at ultrasound examination was Purpose We aim to provide a comprehensive overview of detected by some but not all authors. the role of the vagina as a route for drug delivery and Conclusions The vaginal route represents a scarcely absorption, with a particular focus on the use of vaginal explored modality for drug administration. High local hormonal compounds for the treatment of deep inﬁltrating hormonal concentrations might achieve a greater effect on symptomatic endometriosis. endometriotic lesions compared with alternative routes. Methods A MEDLINE search through PubMed was per- Future studies should focus on the use of the vagina for formed to identify all published studies in English language delivering target therapies particularly in patients with on vaginal hormonal treatments for symptomatic deeply inﬁltrating rectovaginal lesions. endometriosis. Results Main advantages of
Archives of Gynecology and Obstetrics – Springer Journals
Published: Jun 29, 2017
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