Reactions 1704, p298 - 2 Jun 2018
Lichen planus: case report
A 53-year-old woman developed lichen planus following
treatment with peginterferon-α-2b for chronic hepatitis B
The woman, who had chronic hepatitis B infection, started
receiving treatment with SC peginterferon-α-2b 1.5 µg/kg
weekly for 48 weeks. At 21 weeks of interferon therapy, she
developed burning, sharp sensation in the mouth that
worsened with cold food. She completed a total of 48 weeks of
peginterferon-α-2b therapy. Examination revealed atrophic
and ulcerated erythematous plaques on the buccal mucosal
surface with white striae. Incisional biopsy showed a lichenoid
lymphoplasmacytic infiltrate in the subepithelial stroma.
Overlying squamous epithelium revealed sawtoothed rete
ridges, neutrophilic and lymphocytic exocytosis, occasional
apoptotic keratinocytes, intercellular oedema and
parakeratosis. Based on these findings, she was diagnosed
with oral lichen planus.
The woman was treated with triamcinolone dental paste.
She showed an improvement in pain and burning discomfort
over the next 4 weeks, with decrease in the ulcer.
Author comment: "[Lichen planus] has also been reported
to develop or worsen with interferon therapy, largely in the
context of hepatitis C." "We report a case of erosive oral
lichen planus after peginterferon therapy for chronic hepatitis
Choi E, et al. Interferon treatment associated oral lichen planus in a patient with
chronic hepatitis B. Australasian Journal of Dermatology 59 (Suppl. 1): 49, May
2018. Available from: URL: http://doi.org/10.1111/ajd.17_12815 [abstract] -
Reactions 2 Jun 2018 No. 17040114-9954/18/1704-0001/$14.95 Adis © 2018 Springer International Publishing AG. All rights reserved