Peginterferon-α-2b

Peginterferon-α-2b Reactions 1704, p298 - 2 Jun 2018 Lichen planus: case report A 53-year-old woman developed lichen planus following treatment with peginterferon-α-2b for chronic hepatitis B infection. The woman, who had chronic hepatitis B infection, started receiving treatment with SC peginterferon-α-2b 1.5 µg/kg weekly for 48 weeks. At 21 weeks of interferon therapy, she developed burning, sharp sensation in the mouth that worsened with cold food. She completed a total of 48 weeks of peginterferon-α-2b therapy. Examination revealed atrophic and ulcerated erythematous plaques on the buccal mucosal surface with white striae. Incisional biopsy showed a lichenoid lymphoplasmacytic infiltrate in the subepithelial stroma. Overlying squamous epithelium revealed sawtoothed rete ridges, neutrophilic and lymphocytic exocytosis, occasional apoptotic keratinocytes, intercellular oedema and parakeratosis. Based on these findings, she was diagnosed with oral lichen planus. The woman was treated with triamcinolone dental paste. She showed an improvement in pain and burning discomfort over the next 4 weeks, with decrease in the ulcer. Author comment: "[Lichen planus] has also been reported to develop or worsen with interferon therapy, largely in the context of hepatitis C." "We report a case of erosive oral lichen planus after peginterferon therapy for chronic hepatitis B infection." Choi E, et al. Interferon treatment associated oral lichen planus in a patient with chronic hepatitis B. Australasian Journal of Dermatology 59 (Suppl. 1): 49, May 2018. Available from: URL: http://doi.org/10.1111/ajd.17_12815 [abstract] - Singapore 803323589 0114-9954/18/1704-0001/$14.95 Adis © 2018 Springer International Publishing AG. All rights reserved Reactions 2 Jun 2018 No. 1704 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Reactions Weekly Springer Journals

Peginterferon-α-2b

Reactions Weekly , Volume 1704 (1) – Jun 2, 2018
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Publisher
Springer Journals
Copyright
Copyright © 2018 by Springer International Publishing AG, part of Springer Nature
Subject
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
ISSN
0114-9954
eISSN
1179-2051
D.O.I.
10.1007/s40278-018-46941-2
Publisher site
See Article on Publisher Site

Abstract

Reactions 1704, p298 - 2 Jun 2018 Lichen planus: case report A 53-year-old woman developed lichen planus following treatment with peginterferon-α-2b for chronic hepatitis B infection. The woman, who had chronic hepatitis B infection, started receiving treatment with SC peginterferon-α-2b 1.5 µg/kg weekly for 48 weeks. At 21 weeks of interferon therapy, she developed burning, sharp sensation in the mouth that worsened with cold food. She completed a total of 48 weeks of peginterferon-α-2b therapy. Examination revealed atrophic and ulcerated erythematous plaques on the buccal mucosal surface with white striae. Incisional biopsy showed a lichenoid lymphoplasmacytic infiltrate in the subepithelial stroma. Overlying squamous epithelium revealed sawtoothed rete ridges, neutrophilic and lymphocytic exocytosis, occasional apoptotic keratinocytes, intercellular oedema and parakeratosis. Based on these findings, she was diagnosed with oral lichen planus. The woman was treated with triamcinolone dental paste. She showed an improvement in pain and burning discomfort over the next 4 weeks, with decrease in the ulcer. Author comment: "[Lichen planus] has also been reported to develop or worsen with interferon therapy, largely in the context of hepatitis C." "We report a case of erosive oral lichen planus after peginterferon therapy for chronic hepatitis B infection." Choi E, et al. Interferon treatment associated oral lichen planus in a patient with chronic hepatitis B. Australasian Journal of Dermatology 59 (Suppl. 1): 49, May 2018. Available from: URL: http://doi.org/10.1111/ajd.17_12815 [abstract] - Singapore 803323589 0114-9954/18/1704-0001/$14.95 Adis © 2018 Springer International Publishing AG. All rights reserved Reactions 2 Jun 2018 No. 1704

Journal

Reactions WeeklySpringer Journals

Published: Jun 2, 2018

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