Curr Pediatr Rep (2017) 5:167–175 DOI 10.1007/s40124-017-0137-4 GASTROLOGY (S KHAN, SECTION EDITOR) 1 2 Kristin N. Fiorino & Manu R. Sood Published online: 10 July 2017 Springer Science + Business Media New York 2017 Abstract Keywords Gastrointestinal dysmotility Enteric nervous . . . Purpose of Review Pediatric gastrointestinal motility disor- system (ENS) Achalasia Gastroparesis Chronic intestinal ders are a heterogeneous group of enteric nervous system pseudoobstruction syndrome (CIP) Hirschsprung’s disease disorders that continue to cause difficulties in children. The (HD) pathophysiology, diagnosis, and treatments of the most com- mon disorders of the esophagus, stomach, small intestine, and colon will be discussed to understand the interplay between Introduction motility and sensory functions and the effect on gastrointesti- nal motility. Propulsion of gastrointestinal (GI) luminal contents requires Recent Findings Much remains unanswered in the pathogen- coordinated contractions of intestinal smooth muscle in re- esis of the majority intestinal motility disorders. Research has sponse to input from enteric neurons . The enteric nervous started to explore targeted gene mutations as potential causes system is capable of independent function, modulated by mo- of congenital motility disorders, which may be able to help tor input from the brain through the sympathetic and parasym- better
Current Pediatrics Reports – Springer Journals
Published: Jul 10, 2017
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