Pharm Res (2018) 35: 145 https://doi.org/10.1007/s11095-018-2428-z RESEARCH PAPER Pectin and Mucin Enhance the Bioadhesion of Drug Loaded Nanofibrillated Cellulose Films 1 1 2 3 1 Patrick Laurén & Heli Paukkonen & Tiina Lipiäinen & Yujiao Dong & Timo Oksanen & 2 2 3 1,4 1,5 Heikki Räikkönen & Henrik Ehlers & Päivi Laaksonen & Marjo Yliperttula & Timo Laaksonen Received: 1 February 2018 /Accepted: 9 May 2018 /Published online: 22 May 2018 # Springer Science+Business Media, LLC, part of Springer Nature 2018 ABSTRACT film polymer composition. All bioadhesive components were Purpose Bioadhesion is an important property of biological non-toxic and showed high adhesiveness. Rapid drug release membranes, that can be utilized in pharmaceutical and bio- was observed, as 60–80% of the total amount of metronida- medical applications. In this study, we have fabricated zole was released in 30 min depending on the film mucoadhesive drug releasing films with bio-based, non-toxic formulation. and biodegradable polymers that do not require chemical Conclusions The liquid molding used was a straightforward modifications. and simple method to produce drug releasing highly mucoad- Methods Nanofibrillar cellulose and anionic type nanofibril- hesive films, which could be utilized in treating local oral dis- lar cellulose were used
Pharmaceutical Research – Springer Journals
Published: May 22, 2018
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera