Pectin and Mucin Enhance the Bioadhesion of Drug Loaded Nanofibrillated Cellulose Films

Pectin and Mucin Enhance the Bioadhesion of Drug Loaded Nanofibrillated Cellulose Films Pharm Res (2018) 35: 145 https://doi.org/10.1007/s11095-018-2428-z RESEARCH PAPER Pectin and Mucin Enhance the Bioadhesion of Drug Loaded Nanofibrillated Cellulose Films 1 1 2 3 1 Patrick Laurén & Heli Paukkonen & Tiina Lipiäinen & Yujiao Dong & Timo Oksanen & 2 2 3 1,4 1,5 Heikki Räikkönen & Henrik Ehlers & Päivi Laaksonen & Marjo Yliperttula & Timo Laaksonen Received: 1 February 2018 /Accepted: 9 May 2018 /Published online: 22 May 2018 # Springer Science+Business Media, LLC, part of Springer Nature 2018 ABSTRACT film polymer composition. All bioadhesive components were Purpose Bioadhesion is an important property of biological non-toxic and showed high adhesiveness. Rapid drug release membranes, that can be utilized in pharmaceutical and bio- was observed, as 60–80% of the total amount of metronida- medical applications. In this study, we have fabricated zole was released in 30 min depending on the film mucoadhesive drug releasing films with bio-based, non-toxic formulation. and biodegradable polymers that do not require chemical Conclusions The liquid molding used was a straightforward modifications. and simple method to produce drug releasing highly mucoad- Methods Nanofibrillar cellulose and anionic type nanofibril- hesive films, which could be utilized in treating local oral dis- lar cellulose were used http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Pharmaceutical Research Springer Journals

Pectin and Mucin Enhance the Bioadhesion of Drug Loaded Nanofibrillated Cellulose Films

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Publisher
Springer US
Copyright
Copyright © 2018 by Springer Science+Business Media, LLC, part of Springer Nature
Subject
Biomedicine; Pharmacology/Toxicology; Pharmacy; Biochemistry, general; Medical Law; Biomedical Engineering
ISSN
0724-8741
eISSN
1573-904X
D.O.I.
10.1007/s11095-018-2428-z
Publisher site
See Article on Publisher Site

Abstract

Pharm Res (2018) 35: 145 https://doi.org/10.1007/s11095-018-2428-z RESEARCH PAPER Pectin and Mucin Enhance the Bioadhesion of Drug Loaded Nanofibrillated Cellulose Films 1 1 2 3 1 Patrick Laurén & Heli Paukkonen & Tiina Lipiäinen & Yujiao Dong & Timo Oksanen & 2 2 3 1,4 1,5 Heikki Räikkönen & Henrik Ehlers & Päivi Laaksonen & Marjo Yliperttula & Timo Laaksonen Received: 1 February 2018 /Accepted: 9 May 2018 /Published online: 22 May 2018 # Springer Science+Business Media, LLC, part of Springer Nature 2018 ABSTRACT film polymer composition. All bioadhesive components were Purpose Bioadhesion is an important property of biological non-toxic and showed high adhesiveness. Rapid drug release membranes, that can be utilized in pharmaceutical and bio- was observed, as 60–80% of the total amount of metronida- medical applications. In this study, we have fabricated zole was released in 30 min depending on the film mucoadhesive drug releasing films with bio-based, non-toxic formulation. and biodegradable polymers that do not require chemical Conclusions The liquid molding used was a straightforward modifications. and simple method to produce drug releasing highly mucoad- Methods Nanofibrillar cellulose and anionic type nanofibril- hesive films, which could be utilized in treating local oral dis- lar cellulose were used

Journal

Pharmaceutical ResearchSpringer Journals

Published: May 22, 2018

References

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