Pd nanoparticles: an efficient catalyst for the solvent-free synthesis of 2,3-disubstituted-4-thiazolidinones

Pd nanoparticles: an efficient catalyst for the solvent-free synthesis of... Ph Ph Ph H O HS O OH Pd(OAc)2 aq.NaBH4 RT 9-Decen-1-ol Pd Nanoparticle Ph N synthesis OH OH Ph & Murlidhar S. Shingare prof_msshingare@rediffmail.com Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad 431004, India 123 6696 R. R. Harale et al. Keywords 4-Thiazolidinones  Cyclocondensation reaction  Palladium nanoparticles Introduction 4-Thiazolidinone derivatives are of considerable and remarkable interest in the field of medicinal chemistry. The 4-thiazolidinone heterocycles exhibit a wide range of biological activities such as anti-cancer [1], anti-malarial [2], anti-bacterial [3], anti- HIV [4] and nematicidal [5] activities, etc. Moreover, their end derivatives are also important precursors for the synthesis of useful pharmaceutical compounds, such as pyrazolothiazole derivatives [6], monofluoro b-lactam [7] and also for the synthesis of polymethine cyanine dyes [8]. Due to this diversity of the motif in the biological profile, 4-thiazolidinones have attracted much attention of the research community to explore the catalytic pathways for its synthesis. The most recently used methods for the synthesis of thiazolidinone include condensation of aldehydes, anilines and mercaptoacetic acid using catalyst such as DCC [9], Saccharomyces cerevisiae [10], HBTU [11], [bmim][PF ][12], Bi(SCH COOH) [13], silica chloride [14], silica gel [15], etc. Attempts have also 2 3 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Research on Chemical Intermediates Springer Journals

Pd nanoparticles: an efficient catalyst for the solvent-free synthesis of 2,3-disubstituted-4-thiazolidinones

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Springer Netherlands
Copyright © 2016 by Springer Science+Business Media Dordrecht
Chemistry; Catalysis; Physical Chemistry; Inorganic Chemistry
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