PCSK9i therapy projected to have low budget impact in USA

PCSK9i therapy projected to have low budget impact in USA PharmacoEconomics & Outcomes News 792, p23 - 2 Dec 2017 PCSK9i therapy projected to have low budget impact in USA Add-on treatment with an PCSK9 inhibitor (PCSK9i; alirocumab or evolocumab) for further reduction of LDL cholesterol levels in statin -treated adults with heterozygous familial hypercholesterolemia or clinical atherosclerotic cardiovascular disease is projected to have a low budget impact in the USA, according to findings of a Sanofi/Regeneron-funded analysis published in PharmacoEconomics. A model was used to evaluate the budget impact of add-on alirocumab or evolocumab in 27 844 target patients with uncontrolled LDL cholesterol despite statin treatment, compared with statins alone, over a three- year time horizon in a hypothetical US healthcare plan with one million members. As a separate scenario, the budget impact of PCSK9i was also calculated from the perspective of commercial and Medicare Advantage health plans. Assumed total annual costs of lipid modifying therapy including PCSK9 inhibitor costs were ** $14 563.50. The estimated total healthcare budget impact during year 1, 2 and 3 was $3.62, $7.22 and $10.79 per target patient per month (PPPM), respectively, at up to 5% PCSK9i utilisation, and $15.81, $31.52 and $47.12, respectively, at 5%–10% utilisation. The estimated budget impact per member per month during year 1, 2 and 3 was only $0.10, $0.20 and $0.30, respectively, at up to 5% PCSK9i utilisation, and $0.44, $0.88 and $1.31, respectively, at 5%–10% utilisation. The introduction of PCSK9i would yield a net total healthcare budget increase of $1.21 million, $2.43 million and $3.66 million during years 1, 2 and 3, respectively ($7.30 million over 3 years). Increased utilisation of PCSK9i would result in 3-year cardiovascular event-related cost savings of $2.02 million. Assuming a PCSK9i utilisation rate of up to 5%, 3-year total healthcare costs were estimated to increase by $8.08 PPPM for a commercial health plan compared with the reference scenario, and by $6.26 PPPM for a Medicare Advantage health plan. Results were sensitive to the time horizon, the number of years to maximum PCSK9i utilisation, and PCSK9i costs. "These findings suggest that the PCSK9i alirocumab and evolocumab, at wholesale acquisition cost, are likely to have a smaller impact on US healthcare plans compared with prior estimates," said the authors. "If the manufacturers offer rebates and discounts to the list price, the budget impact would be lower than the results presented herein," they noted. * HMG-CoA reductase inhibitor ** 2017 US dollars Mallya UG, et al. Budget Impact Analysis of PCSK9 Inhibitors for the Management of Adult Patients with Heterozygous Familial Hypercholesterolemia or Clinical Atherosclerotic Cardiovascular Disease. PharmacoEconomics : 27 Nov 2017. Available from: URL: https://doi.org/10.1007/ s40273-017-0590-5 1173-5503/17/0792-0001/$14.95 Adis © 2017 Springer International Publishing AG. All rights reserved PharmacoEconomics & Outcomes News 2 Dec 2017 No. 792 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png PharmacoEconomics & Outcomes News Springer Journals

PCSK9i therapy projected to have low budget impact in USA

1 page

Loading next page...
1 Page
Springer International Publishing
Copyright © 2017 by Springer International Publishing AG, part of Springer Nature
Medicine & Public Health; Pharmacoeconomics and Health Outcomes; Quality of Life Research; Health Economics; Public Health
Publisher site
See Article on Publisher Site

There are no references for this article.

You’re reading a free preview. Subscribe to read the entire article.

DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 12 million articles from more than
10,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Unlimited reading

Read as many articles as you need. Full articles with original layout, charts and figures. Read online, from anywhere.

Stay up to date

Keep up with your field with Personalized Recommendations and Follow Journals to get automatic updates.

Organize your research

It’s easy to organize your research with our built-in tools.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

Monthly Plan

  • Read unlimited articles
  • Personalized recommendations
  • No expiration
  • Print 20 pages per month
  • 20% off on PDF purchases
  • Organize your research
  • Get updates on your journals and topic searches


Start Free Trial

14-day Free Trial

Best Deal — 39% off

Annual Plan

  • All the features of the Professional Plan, but for 39% off!
  • Billed annually
  • No expiration
  • For the normal price of 10 articles elsewhere, you get one full year of unlimited access to articles.



billed annually
Start Free Trial

14-day Free Trial