Pazopanib Reactions 1680, p275 - 2 Dec 2017 Malaise and aspartate aminotransferase elevation: case report An adult man in his 20’s [exact age not stated] developed malaise and aspartate aminotransferase elevation during treatment with pazopanib [time to reaction onsets and outcomes not stated]. The man presented in March 2016 at the age of 23 years with a tongue swelling and was diagnosed with alveolar soft part sarcoma in May 2016. He underwent a complete excision of the mass in June. In September, he developed a recurrence of the alveolar soft part sarcoma and was started on combination therapy with doxorubicin and ifosfamide. However, the mass continued to grow rapidly and the regimen was withheld, and he was started on monotherapy with oral pazopanib 800 mg/day in October. Subsequently, he developed grade 1 malaise and aspartate aminotransferase elevation of 56 U/L. Author comment: "Pazopanib was well tolerated and the patient experienced no severe adverse events other than Grade 1 malaise, aspartate aminotransferase elevation (56 U/l) according to the Common Terminology Criteria for Adverse Events". Yoshihiro T, et al. Lingual alveolar soft part sarcoma responsive to pazopanib: A case report. Medicine 96: e8470, No. 44, Nov 2017. Available from: URL: http:// - Japan 803285342 0114-9954/17/1680-0001/$14.95 Adis © 2017 Springer International Publishing AG. All rights reserved Reactions 2 Dec 2017 No. 1680 Reactions Weekly Springer Journals


Reactions Weekly , Volume 1680 (1) – Dec 2, 2017
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Springer International Publishing
Copyright © 2017 by Springer International Publishing AG, part of Springer Nature
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
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