Support Care Cancer (2018) 26:1133–1142 https://doi.org/10.1007/s00520-017-3934-y ORIGINAL ARTICLE Patients with advanced periodontal disease before intensity-modulated radiation therapy are prone to develop bone healing problems: a 2-year prospective follow-up study 1 1,2 1 Jennifer M. Schuurhuis & Monique A. Stokman & Max J. H. Witjes & 1 2 1 Harry Reintsema & Johannes A. Langendijk & Arjan Vissink & Frederik K. L. Spijkervet Received: 19 January 2017 /Accepted: 16 October 2017 /Published online: 31 October 2017 The Author(s) 2017. This article is an open access publication Abstract that the periodontal inflamed surface area, which is higher in Purpose Intensity-modulated radiation therapy (IMRT) has patients with more severe periodontal disease, predicted that a changed radiation treatment of head and neck cancer (HNC). patient has a higher risk on developing osteoradionecrosis or However, it is still unclear if and how IMRT changes oral bone healing problems (p =0.028). morbidity outcomes. In this prospective study, we assessed Conclusions Patients with severe periodontal disease before the outcome of reducing post-IMRT sequelae by means of IMRT/CHIMRT are more prone to develop bone healing pre-radiation dental screening and eliminating oral foci. problems post-radiotherapy. Methods All consecutive dentate patients > 18 years, diag- nosed with primary oral
Supportive Care in Cancer – Springer Journals
Published: Oct 31, 2017
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