Pathological and microbiological findings from mortality of the Chinese giant salamander ( Andrias davidianus )

Pathological and microbiological findings from mortality of the Chinese giant salamander (... The Chinese giant salamander, Andrias davidianus , is a nationally protected and cultured species in China. Recently, a severe epizootic occurred in cultured Chinese giant salamanders in Hubei, Hunan, Sichuan, Shaanxi, and Zhejiang provinces of China, causing substantial economic losses. The typical clinical signs of diseased larval animals were jaw and abdominal swelling and subcutaneous hemorrhaging. Diseased adult animals exhibited skin hemorrhages, ulceration of the hind limbs, and multiple hemorrhagic spots in the visceral organs. Histopathological observation indicated tissue necrosis and cytoplasmic inclusions in the spleen, liver and kidney, suggestive of viral disease. A viral agent was isolated from affected tissues in cell culture. The virus was determined to be pathogenic after experimental infection. Electron microscopy revealed iridovirus-like virions with a size of 140-180 nm in diameter inside the kidney of naturally infected animals and in cell culture. The major capsid protein (MCP) of the virus exhibited 98-99 % sequence identity to ranaviruses. Additionally, phylogenetic analysis indicated that the virus belonged to the genus Ranavirus . Comparative analysis of the MCP gene sequence with those of other viruses previously isolated from Chinese giant salamanders revealed that these isolates were highly similar, although a few variations were observed. The virus was preliminarily named Chinese giant salamander iridovirus (GSIV). Archives of Virology Springer Journals

Pathological and microbiological findings from mortality of the Chinese giant salamander ( Andrias davidianus )

Loading next page...
Springer Vienna
Copyright © 2014 by Springer-Verlag Wien
Biomedicine; Virology; Medical Microbiology; Infectious Diseases
Publisher site
See Article on Publisher Site


  • Outbreaks of an iridovirus in marbled sleepy goby, Oxyeleotris marmoratus (Bleeker), cultured in southern China
    Wang, Q; Zeng, WW; Li, KB; Chang, OQ; Liu, C; Wu, GH; Shi, CB; Wu, SQ
  • Iridovirus infections in finfish-critical review with emphasis on ranaviruses
    Whittington, RJ; Becker, JA; Dennis, MM
  • Molecular characterization of iridoviruses isolated from sympatric amphibians and fish
    Mao, JH; Green, DE; Fellers, G; Chinchar, VG
  • Ranavirus-associated mass mortality in wild amphibians, The Netherlands, 2010, a first report
    Kik, M; Martel, A; Sluijs, AS; Pasmans, F; Wohlsein, P; Grone, A; Rijks, JM
  • Outbreak of common midwife toad virus in alpine newts ( Mesotriton alpestris cyreni ) and common midwife toads ( Alytes obstetricans ) in Northern Spain. A comparative pathological study of an emerging ranavirus
    Baslserio, A; Dalton, KP; Cerro, DA; Márquez, I; Parra, F; Prieto, JM; Casais, R

You’re reading a free preview. Subscribe to read the entire article.

DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 12 million articles from more than
10,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Unlimited reading

Read as many articles as you need. Full articles with original layout, charts and figures. Read online, from anywhere.

Stay up to date

Keep up with your field with Personalized Recommendations and Follow Journals to get automatic updates.

Organize your research

It’s easy to organize your research with our built-in tools.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

Monthly Plan

  • Read unlimited articles
  • Personalized recommendations
  • No expiration
  • Print 20 pages per month
  • 20% off on PDF purchases
  • Organize your research
  • Get updates on your journals and topic searches


Start Free Trial

14-day Free Trial

Best Deal — 39% off

Annual Plan

  • All the features of the Professional Plan, but for 39% off!
  • Billed annually
  • No expiration
  • For the normal price of 10 articles elsewhere, you get one full year of unlimited access to articles.



billed annually
Start Free Trial

14-day Free Trial