Pathogenesis of non-functioning pituitary adenomas

Pathogenesis of non-functioning pituitary adenomas The pathogenesis of non functioning pituitary adenomas (NFPA) is a complex process involving several factors, from molecular to genetic and epigenetic modifications, where tumor suppressor genes, oncogenes, cell cycle derangements have been demonstrated to play an important role. MicroRNAs (miRNAs) have also been identified as possible players in NFPA tumorigenesis and pituitary stem cells have been investigated for their potential role in pituitary tumor initiation. However, a critical role for paracrine signalling has also been highlighted. This review focuses on the current knowledge on the involvement of these factors in NFPA pathogenesis. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Pituitary Springer Journals

Pathogenesis of non-functioning pituitary adenomas

Pituitary , Volume 21 (2) – Feb 5, 2018
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Publisher
Springer US
Copyright
Copyright © 2018 by Springer Science+Business Media, LLC, part of Springer Nature
Subject
Medicine & Public Health; Diabetes; Human Physiology
ISSN
1386-341X
eISSN
1573-7403
D.O.I.
10.1007/s11102-018-0874-6
Publisher site
See Article on Publisher Site

Abstract

The pathogenesis of non functioning pituitary adenomas (NFPA) is a complex process involving several factors, from molecular to genetic and epigenetic modifications, where tumor suppressor genes, oncogenes, cell cycle derangements have been demonstrated to play an important role. MicroRNAs (miRNAs) have also been identified as possible players in NFPA tumorigenesis and pituitary stem cells have been investigated for their potential role in pituitary tumor initiation. However, a critical role for paracrine signalling has also been highlighted. This review focuses on the current knowledge on the involvement of these factors in NFPA pathogenesis.

Journal

PituitarySpringer Journals

Published: Feb 5, 2018

References

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