In recent years, the modeling and simulation of biochemical networks has attracted increasing attention. Such networks are commonly modeled by systems of ordinary differential equations, a special class of which are known as S-systems. These systems are specifically designed to mimic kinetic reactions, and are sufficiently general to model genetic networks, metabolic networks, and signal transduction cascades. The parameters of an S-system correspond to various kinetic rates of the underlying reactions, and one of the main challenges is to determine approximate values of these parameters, given measured (or simulated) time traces of the involved reactants.
Reliable Computing – Springer Journals
Published: Jul 29, 2006
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