p53 and p16 expression in oral cavity squamous cell and basaloid squamous cell carcinoma

p53 and p16 expression in oral cavity squamous cell and basaloid squamous cell carcinoma Purpose The true aggressive behavior of oral cavity BSCC compared to SCC has been debated, and the study of disturbances in cell cycle proteins may help understand the biological behavior in both variants. The aim of this study was to investigate the p53 and p16 status in 32 SCC and 16 BSCC of oral cavity. Methods Immunohistochemistry was used to assess these proteins’ status. The association between p53 and p16 with clinico- pathological features and prognostic value were evaluated. Results A high prevalence of p53 disruption was observed in both variants (84.4% of 32—SCC and 81.2% of 16—BSCC; p = 0.78). The BSCC showed a higher prevalence of high p16 expression (86.7% of 15) when compared to SCC (61.3% of 31); however, this difference did not reach statistical significance ( p = 0.08). In the SCC variant, cases with high p16 expression showed a lower overall survival. Protein p53 showed association with tobacco use, but with no other clinico- pathological features. Conclusions Our results suggest that p53 and p16 cell cycle disruptions are common findings in oral cavity SCC, as well as in BSCC. A higher prevalence of p16 overexpression in oral BSCC cases may be related to carcinogenesis process. Keywords Squamous cell http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Oral Cancer Springer Journals

p53 and p16 expression in oral cavity squamous cell and basaloid squamous cell carcinoma

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Publisher
Springer International Publishing
Copyright
Copyright © 2018 by Springer International Publishing AG, part of Springer Nature
Subject
Dentistry; Dentistry; Oral and Maxillofacial Surgery; Oncology
eISSN
2509-8837
D.O.I.
10.1007/s41548-018-0004-1
Publisher site
See Article on Publisher Site

Abstract

Purpose The true aggressive behavior of oral cavity BSCC compared to SCC has been debated, and the study of disturbances in cell cycle proteins may help understand the biological behavior in both variants. The aim of this study was to investigate the p53 and p16 status in 32 SCC and 16 BSCC of oral cavity. Methods Immunohistochemistry was used to assess these proteins’ status. The association between p53 and p16 with clinico- pathological features and prognostic value were evaluated. Results A high prevalence of p53 disruption was observed in both variants (84.4% of 32—SCC and 81.2% of 16—BSCC; p = 0.78). The BSCC showed a higher prevalence of high p16 expression (86.7% of 15) when compared to SCC (61.3% of 31); however, this difference did not reach statistical significance ( p = 0.08). In the SCC variant, cases with high p16 expression showed a lower overall survival. Protein p53 showed association with tobacco use, but with no other clinico- pathological features. Conclusions Our results suggest that p53 and p16 cell cycle disruptions are common findings in oral cavity SCC, as well as in BSCC. A higher prevalence of p16 overexpression in oral BSCC cases may be related to carcinogenesis process. Keywords Squamous cell

Journal

Oral CancerSpringer Journals

Published: Jan 22, 2018

References

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