p-Sulfonic acid calixarene as an efﬁcient
and reusable catalyst for the synthesis of acridinediones
Seyed Meysam Baghbanian
Seyed Mohammad Vahdat
Received: 2 December 2014 / Accepted: 5 March 2015 / Published online: 26 May 2015
Ó Springer Science+Business Media Dordrecht 2015
Abstract p-Sulfonic acid calixarene has been found to be an efﬁcient catalyst
for the synthesis of acridinediones and xanthenes under mild conditions in excellent
yields. The present approach offers the advantages of simple methodology, short
reaction time, and high yield.
Keywords p-Sulfonic acid calixarene Á Organocatalyst Á Xanthenes Á
Multi-component reactions play an important role in combinatorial chemistry
because of their ability to synthesize small drug-like molecules with several degrees
of structural diversity. These one-pot reactions introduce the most efﬁcient method
to the molecular diversity .
Acridine derivatives possess a wide range of pharmaceutical activities, including
antibacterial , antitumor , anticancer , fungicidal , and DNA-binding
Xanthene derivatives are very important heterocyclic compounds because of their
wide range of biological and pharmaceutical properties such as anti-inﬂammatory
, antibacterial , antiviral , photodynamic therapy , and antiviral .
Electronic supplementary material The online versionof this article (doi:10.1007/s11164-015-2001-x)
contains supplementary material, which is available to authorized users.
& Seyed Meysam Baghbanian
Department of Chemistry, Ayatollah Amoli Branch, Islamic Azad University, 698, Amol, Iran
Cellular and Molecular Biology Research Center (CMBRC), Babol University of Medical
Sciences, Babol, Iran
Res Chem Intermed (2015) 41:9951–9966