Oxytocin and prostaglandins F 2α and E 2 do not enhance HIV antigen production in vitro

Oxytocin and prostaglandins F 2α and E 2 do not enhance HIV antigen production in vitro Oxytocin and prostaglandins (PGs) are hormones involved in labor and are used clinically for its induction. In this study the effect of oxytocin, PGF 2α , and PGE 2 on Humour immunodeficiency virus-1 production in acutely and persistently infected cells was measured. No significant effect on p24 antigen production was found with oxytocin or PGs, except for a transient decrease in persistently infected cells treated with 1 µM PGF 2α . These results showed that oxytocin and PGs could be used clinically for labor induction without any direct enhancement in viral production. Besides, the results with PGF 2α at the highest concentration studied may indicate a pharmacological effect. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Virology Springer Journals

Oxytocin and prostaglandins F 2α and E 2 do not enhance HIV antigen production in vitro

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Publisher
Springer Journals
Copyright
Copyright © 2002 by Springer-Verlag/Wien
Subject
Legacy
ISSN
0304-8608
eISSN
1432-8798
D.O.I.
10.1007/s00705-002-0940-1
Publisher site
See Article on Publisher Site

Abstract

Oxytocin and prostaglandins (PGs) are hormones involved in labor and are used clinically for its induction. In this study the effect of oxytocin, PGF 2α , and PGE 2 on Humour immunodeficiency virus-1 production in acutely and persistently infected cells was measured. No significant effect on p24 antigen production was found with oxytocin or PGs, except for a transient decrease in persistently infected cells treated with 1 µM PGF 2α . These results showed that oxytocin and PGs could be used clinically for labor induction without any direct enhancement in viral production. Besides, the results with PGF 2α at the highest concentration studied may indicate a pharmacological effect.

Journal

Archives of VirologySpringer Journals

Published: Feb 1, 2003

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