Oxidative stress and inflammation: new molecular targets for cardiovascular diseases

Oxidative stress and inflammation: new molecular targets for cardiovascular diseases Internal and Emergency Medicine (2018) 13:647–649 https://doi.org/10.1007/s11739-018-1865-3 IM - COMMENTARY Oxidative stress and inflammation: new molecular targets for cardiovascular diseases 1 1 1 1 Matteo Becatti  · Amanda Mannucci  · Niccolò Taddei  · Claudia Fiorillo Received: 17 April 2018 / Accepted: 22 April 2018 / Published online: 1 June 2018 © SIMI 2018 Coronary artery disease (CAD) is the underlying condition Neutrophil extracellular traps (NETs) have been identified in most acute coronary events and the leading cause of death in 2004 as a new neutrophil pathogen-killing mechanism, in developed countries [1]. The previous studies have shown and have been proven beneficial against infections [ 19]. that oxidative stress, a condition caused by an imbalance NETs are extracellular DNA fibers comprising histones and between reactive oxygen species (ROS) production and anti- neutrophil antimicrobial proteins. Extracellular DNA traps oxidant defense systems and closely associated with many are also observed in inflammatory but noninfectious dis - other chronic and acute disorders [2–12], contributes to the eases, like autoimmune diseases [20] or psoriasis [21]. New initiation and progression of endothelial dysfunction and emerging data describe NETs as the key players of several atherogenesis [13]. Indeed, ROS can damage every cell vascular diseases, such as acute coronary syndrome, stroke, component, http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Internal and Emergency Medicine Springer Journals

Oxidative stress and inflammation: new molecular targets for cardiovascular diseases

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Publisher
Springer Journals
Copyright
Copyright © 2018 by SIMI
Subject
Medicine & Public Health; Internal Medicine
ISSN
1828-0447
eISSN
1970-9366
D.O.I.
10.1007/s11739-018-1865-3
Publisher site
See Article on Publisher Site

Abstract

Internal and Emergency Medicine (2018) 13:647–649 https://doi.org/10.1007/s11739-018-1865-3 IM - COMMENTARY Oxidative stress and inflammation: new molecular targets for cardiovascular diseases 1 1 1 1 Matteo Becatti  · Amanda Mannucci  · Niccolò Taddei  · Claudia Fiorillo Received: 17 April 2018 / Accepted: 22 April 2018 / Published online: 1 June 2018 © SIMI 2018 Coronary artery disease (CAD) is the underlying condition Neutrophil extracellular traps (NETs) have been identified in most acute coronary events and the leading cause of death in 2004 as a new neutrophil pathogen-killing mechanism, in developed countries [1]. The previous studies have shown and have been proven beneficial against infections [ 19]. that oxidative stress, a condition caused by an imbalance NETs are extracellular DNA fibers comprising histones and between reactive oxygen species (ROS) production and anti- neutrophil antimicrobial proteins. Extracellular DNA traps oxidant defense systems and closely associated with many are also observed in inflammatory but noninfectious dis - other chronic and acute disorders [2–12], contributes to the eases, like autoimmune diseases [20] or psoriasis [21]. New initiation and progression of endothelial dysfunction and emerging data describe NETs as the key players of several atherogenesis [13]. Indeed, ROS can damage every cell vascular diseases, such as acute coronary syndrome, stroke, component,

Journal

Internal and Emergency MedicineSpringer Journals

Published: Jun 1, 2018

References

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