Originalien Z Rheumatol 2019 · 78:195–201 Y. H. Lee https://doi.org/10.1007/s00393-018-0492-8 Department of Rheumatology, Korea University Anam Hospital, Korea University College of Medicine, Published online: 4 June 2018 Seoul, Korea (Republic of) © Springer Medizin Verlag GmbH, ein Teil von Springer Nature 2018 Redaktion Overall and sex- and disease U. Müller-Ladner, Bad Nauheim U. Lange, Bad Nauheim subtype-speciﬁc mortality in patients with systemic sclerosis An updated meta-analysis number of studies conducted and their we sought to assess and update the data Introduction small sample sizes, and clinical hetero- on overall and sex- and disease subtype- Systemic sclerosis (SSc) is a multisys- geneity [1–4, 11–13, 15–18, 20, 25–27, speciﬁc SMRs in patients with SSc using tem, inﬂammatory autoimmune disease 29–31, 34, 35, 38, 39]. Therefore, an ac- a meta-analysis approach. characterized by progressive vasculopa- curate and weighted analysis of the SMR thy and ﬁbrosis of the skin and internal is important [22, 23]. In another meta- Materials and methods organs . Major pathological features analysis, researchers reported a 2.72- of SSc include the overproduction and fold increase in overall mortality in pa- Identiﬁcation of eligible studies accumulation of collagen in the skin and tients with SSc compared to the general and
Zeitschrift für Rheumatologie – Springer Journals
Published: Jun 4, 2018
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