Outcomes after percutaneous coronary intervention for chronic total occlusion according to baseline renal function

Outcomes after percutaneous coronary intervention for chronic total occlusion according to... Background Chronic kidney disease (CKD) adversely affects outcomes in patients with coronary artery disease. Data on the impact of renal impairment on prognosis of patients undergoing percutaneous coronary intervention (PCI) for chronic total occlusion (CTO) are scarce. Methods A total of 2002 patients undergoing CTO PCI were stratified according to baseline renal function (group 1: 2 2 estimated glomerular filtration rate [eGFR] ≥ 90 ml/min/1.73 m , group 2: 60 to 89 ml/min/1.73 m , group 3: 30 to 59 ml/ 2 2 min/1.73 m , and group 4: <30 ml/min/1.73 m ). The primary outcome measure was all-cause mortality at a median follow- up of 2.6 (interquartile range 1.1–3.1) years. Results All-cause mortality increased with decreasing renal function (group 1: 5.0%, group 2: 9.5%, group 3: 26.4%, and group 4: 38.7%, log rank p < 0.001). Continuous eGFR values were significantly related with all-cause mortality (adjusted HR 0.98, 95% CI 0.98–0.99, p < 0.001). Procedural failure was associated with all-cause mortality both in patients with an eGFR < 60  ml/min/1.73  m (42.6 vs. 23.7%, adjusted HR 1.59, 95% CI 1.08–2.32, p = 0.02) and in those with an eGFR ≥ 60 ml/min/1.73 m (14.6 vs. 6.5%, adjusted HR 1.73, 95% CI 1.15–2.60, p = 0.009, interaction p = http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Zeitschrift für Kardiologie Springer Journals

Outcomes after percutaneous coronary intervention for chronic total occlusion according to baseline renal function

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Publisher
Springer Berlin Heidelberg
Copyright
Copyright © 2017 by Springer-Verlag GmbH Germany, part of Springer Nature
Subject
Medicine & Public Health; Cardiology
ISSN
0300-5860
eISSN
1861-0692
D.O.I.
10.1007/s00392-017-1179-x
Publisher site
See Article on Publisher Site

Abstract

Background Chronic kidney disease (CKD) adversely affects outcomes in patients with coronary artery disease. Data on the impact of renal impairment on prognosis of patients undergoing percutaneous coronary intervention (PCI) for chronic total occlusion (CTO) are scarce. Methods A total of 2002 patients undergoing CTO PCI were stratified according to baseline renal function (group 1: 2 2 estimated glomerular filtration rate [eGFR] ≥ 90 ml/min/1.73 m , group 2: 60 to 89 ml/min/1.73 m , group 3: 30 to 59 ml/ 2 2 min/1.73 m , and group 4: <30 ml/min/1.73 m ). The primary outcome measure was all-cause mortality at a median follow- up of 2.6 (interquartile range 1.1–3.1) years. Results All-cause mortality increased with decreasing renal function (group 1: 5.0%, group 2: 9.5%, group 3: 26.4%, and group 4: 38.7%, log rank p < 0.001). Continuous eGFR values were significantly related with all-cause mortality (adjusted HR 0.98, 95% CI 0.98–0.99, p < 0.001). Procedural failure was associated with all-cause mortality both in patients with an eGFR < 60  ml/min/1.73  m (42.6 vs. 23.7%, adjusted HR 1.59, 95% CI 1.08–2.32, p = 0.02) and in those with an eGFR ≥ 60 ml/min/1.73 m (14.6 vs. 6.5%, adjusted HR 1.73, 95% CI 1.15–2.60, p = 0.009, interaction p =

Journal

Zeitschrift für KardiologieSpringer Journals

Published: Nov 13, 2017

References

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