J Mater Sci: Mater Med (2018) 29:17 DOI 10.1007/s10856-017-6017-1 CLINICAL APPLICATIONS OF BIOMATERIALS Original Research Osteoinduction and -conduction through absorbable bone substitute materials based on calcium sulfate: in vivo biological behavior in a rabbit model 1 2 2 2 2 ● ● ● ● ● D. Pförringer N. Harrasser H. Mühlhofer M. Kiokekli A. Stemberger 1 3 2 2 ● ● ● M. van Griensven M. Lucke R. Burgkart A. Obermeier Received: 7 October 2017 / Accepted: 5 December 2017 / Published online 9 January 2018 © Springer Science+Business Media, LLC, part of Springer Nature 2017 Abstract Calcium sulfate (CS) can be used as an anti- was detected. All CS preparations showed osteogenesis biotically impregnated bone substitute in a variety of clin- associated to implanted material. Osteoblasts attached ical constellations. Antibiotically loaded bone substitutes directly to the implant surface and revealed osteoid pro- ﬁnd speciﬁc application in orthopedic and trauma surgery to duction, osteocytes were found in newly mineralized bone. prevent or treat bone infections especially in relation to Group C implants (Osteoset ) were subject to quick open bone defects. However, its use as a structural bone degradation within 4 weeks, after 6–8 weeks there were graft reveals
Journal of Materials Science: Materials in Medicine – Springer Journals
Published: Jan 9, 2018
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