Oseltamivir-resistant influenza viruses isolated in South Korea from 2005 to 2010

Oseltamivir-resistant influenza viruses isolated in South Korea from 2005 to 2010 South Korean isolates of oseltamivir-resistant influenza viruses from 2005–2010 were investigated with a total 491 influenza viruses identified from 1702 specimens. Neuraminidase genes from 342 influenza viruses (71 A/H1N1, 74 pandemic A/H1N1 2009, 117 A/H3N2, and 80 B) were analyzed by RT-PCR with molecular markers for oseltamivir resistance. The H274Y mutation in the NA protein was identified in 100 % (n=40) of A/H1N1 viruses circulating in 2008–2009. Influenza A/H1N1 viruses harboring the H274Y substitution exhibited, on average, a 626-fold reduction in oseltamivir susceptibility and clustered with the A/Norway/1736/2007 strain. Close and timely monitoring for resistance to clinically available influenza antivirals should be consistently performed. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Virology Springer Journals

Oseltamivir-resistant influenza viruses isolated in South Korea from 2005 to 2010

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Publisher
Springer Vienna
Copyright
Copyright © 2013 by Springer-Verlag Wien
Subject
Biomedicine; Virology; Medical Microbiology; Infectious Diseases
ISSN
0304-8608
eISSN
1432-8798
D.O.I.
10.1007/s00705-013-1734-3
Publisher site
See Article on Publisher Site

Abstract

South Korean isolates of oseltamivir-resistant influenza viruses from 2005–2010 were investigated with a total 491 influenza viruses identified from 1702 specimens. Neuraminidase genes from 342 influenza viruses (71 A/H1N1, 74 pandemic A/H1N1 2009, 117 A/H3N2, and 80 B) were analyzed by RT-PCR with molecular markers for oseltamivir resistance. The H274Y mutation in the NA protein was identified in 100 % (n=40) of A/H1N1 viruses circulating in 2008–2009. Influenza A/H1N1 viruses harboring the H274Y substitution exhibited, on average, a 626-fold reduction in oseltamivir susceptibility and clustered with the A/Norway/1736/2007 strain. Close and timely monitoring for resistance to clinically available influenza antivirals should be consistently performed.

Journal

Archives of VirologySpringer Journals

Published: Nov 1, 2013

References

  • Global epidemiology of influenza: past and present
    Cox, NJ; Subbarao, K
  • Oseltamivir-resistant pandemic (H1N1) 2009 virus, South Korea
    Yi, H; Lee, JY; Hong, EH; Kim, MS; Kwon, D; Choi, JH; Choi, WY; Kim, KS; Lee, JK; Oh, HB; Kang, C
  • High prevalence of amantadine-resistant influenza A virus isolated in Gyeonggi Province, South Korea, during 2005–2010
    Cho, HG; Choi, JH; Kim, WH; Hong, HK; Yoon, MH; Jho, EH; Kang, C; Lim, YH

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