Organization of the leukocyte receptor cluster (LRC) on human Chromosome 19q13.4

Organization of the leukocyte receptor cluster (LRC) on human Chromosome 19q13.4 A large number of cDNAs coding for killer cell inhibitory receptors (KIR) and immunoglobulin-like transcripts (ILT) have already been described, and some of the respective genes are known to map in 19q13.4. To understand the genetic relationships of these transcripts, some of which may be alleles from polymorphic loci, it is necessary to determine the genomic organization of the region. To do so, we performed long-range restriction enzyme mapping of the 19q13.4 region along with YAC and PAC contig construction. Eighteen genes could be assigned to a chromosomal segment of about 600 kb. Twelve KIR loci are contained within ∼200 kb, bordered by the locus for the Fc receptor for IgA (FCAR) at the telomeric side and by a 150-kb cluster containing ILT loci at the centromeric side. A further region with a maximal size of 135 kb containing at least one ILT gene was identified further centromeric, separated by ∼50 kb from the ILT region near the KIR cluster. The entire KIR/ILT region revealed a considerable degree of genetic polymorphism as shown, for example, by different restriction maps of two sets of PACs spanning the same region. We suggest the designation ``Leukocyte Receptor Cluster'' (LRC) for this chromosomal segment. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Mammalian Genome Springer Journals

Organization of the leukocyte receptor cluster (LRC) on human Chromosome 19q13.4

Loading next page...
 
/lp/springer_journal/organization-of-the-leukocyte-receptor-cluster-lrc-on-human-chromosome-OTG03awAvi
Publisher
Springer Journals
Copyright
Copyright © 1999 by Springer-Verlag New York Inc.
Subject
Life Sciences; Cell Biology; Animal Genetics and Genomics; Human Genetics
ISSN
0938-8990
eISSN
1432-1777
D.O.I.
10.1007/s003359900961
Publisher site
See Article on Publisher Site

Abstract

A large number of cDNAs coding for killer cell inhibitory receptors (KIR) and immunoglobulin-like transcripts (ILT) have already been described, and some of the respective genes are known to map in 19q13.4. To understand the genetic relationships of these transcripts, some of which may be alleles from polymorphic loci, it is necessary to determine the genomic organization of the region. To do so, we performed long-range restriction enzyme mapping of the 19q13.4 region along with YAC and PAC contig construction. Eighteen genes could be assigned to a chromosomal segment of about 600 kb. Twelve KIR loci are contained within ∼200 kb, bordered by the locus for the Fc receptor for IgA (FCAR) at the telomeric side and by a 150-kb cluster containing ILT loci at the centromeric side. A further region with a maximal size of 135 kb containing at least one ILT gene was identified further centromeric, separated by ∼50 kb from the ILT region near the KIR cluster. The entire KIR/ILT region revealed a considerable degree of genetic polymorphism as shown, for example, by different restriction maps of two sets of PACs spanning the same region. We suggest the designation ``Leukocyte Receptor Cluster'' (LRC) for this chromosomal segment.

Journal

Mammalian GenomeSpringer Journals

Published: Feb 1, 1999

There are no references for this article.

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create lists to
organize your research

Export lists, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off