Organization of eukaryotic chromosomes: From Kol’tsov’s studies up to present day

Organization of eukaryotic chromosomes: From Kol’tsov’s studies up to present day N.K. Kol’tsov ideas and views on the organization of eukaryotic chromosomes, including the notion of a giant hereditary molecule (genoneme) and its structural functional organization, are considered. Different approaches to chromosome studies are discussed, ranging from the examination of a chromosome as a stained cell organelle and the visualization of individual chromosomes in a living cell to the identification of topological domains of human and murine chromosomes using 3C and 5C technologies. The prospects of studies of chromosome organization using up-to-date methods of cytology, molecular biology, and bioinformatics are discussed. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Russian Journal of Genetics Springer Journals

Organization of eukaryotic chromosomes: From Kol’tsov’s studies up to present day

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Publisher
SP MAIK Nauka/Interperiodica
Copyright
Copyright © 2013 by Pleiades Publishing, Ltd.
Subject
Biomedicine; Human Genetics; Animal Genetics and Genomics; Microbial Genetics and Genomics
ISSN
1022-7954
eISSN
1608-3369
D.O.I.
10.1134/S1022795413010109
Publisher site
See Article on Publisher Site

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