Ann Surg Oncol (2018) 25:2124–2126 https://doi.org/10.1245/s10434-018-6537-z ED ITORIA L – BREA S T O NCOLO G Y Optimizing Surgical Management of the Axilla After Neoadjuvant Chemotherapy: An Evolving Story Eleftherios P. Mamounas, MD, MPH, FACS Orlando Health University of Florida Health Cancer Center, Orlando, FL For patients with operable breast cancer and clinically downstaged by NAC but are found to have small-volume negative axilla who undergo surgery ﬁrst, sentinel lymph disease in the SLN, either on intraoperative frozen section node biopsy (SLNB) has been established as the gold or on permanent pathologic evaluation. standard for pathologic evaluation of the axilla. When the In a recent issue of the Annals of Surgical Oncology, SLN is negative, no further surgery in the axilla is required. Moo et al. report on a large study from Memorial Sloan Traditionally, intraoperative frozen section (FS) was used Kettering Cancer Center that aimed to determine the sen- to assess SLN status. However, randomized clinical trials sitivity of intraoperative SLN FS after NAC as well as the have shown that selected patients with clinically negative association between volume of disease in the SLN (by FS axilla and limited SLN involvement can be spared from or permanent section)
Annals of Surgical Oncology – Springer Journals
Published: May 30, 2018
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