Optimizing bone cement stiffness for vertebroplasty through biomechanical effects analysis based on patient-specific three-dimensional finite element modeling

Optimizing bone cement stiffness for vertebroplasty through biomechanical effects analysis based... Vertebroplasty is a common and effective treatment for symptomatic osteoporotic vertebral compression fractures. However, the cemented and adjacent vertebras have a risk of recollapse due to largely unassured mechanisms, among which excessive stiffness of bone cement may be an important risk factor. This study aimed to find the most appropriate range of bone cement stiffness by analyzing its biomechanical effects on the augmented and adjacent vertebras of individual patient after vertebroplasty. A three-dimensional finite element model of T11-L1 osteoligamentous vertebras was reconstructed according to individual computed tomography data and validated by post mortem human subject experiment in literatures. Bone cement of varying stiffness was injected into the trabecular core of the T12 vertebra simulatively. The maximum von Mises stresses on cancellous and cortical bones of T11-L1 vertebras were analyzed under the loading conditions of flexion, extension, bending, and torsion. For the adjacent T11 and L1 vertebras, the stepwise elevation of the bone cement elastic modulus increased the maximum von Mises stress on the cancellous bone, but its effect on cortical bone was negligible. For the augmented T12 vertebra, the stresses on cancellous bone increased slightly under the loading condition of lateral bending and remained no impact on cortical bone. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Medical & Biological Engineering & Computing Springer Journals

Optimizing bone cement stiffness for vertebroplasty through biomechanical effects analysis based on patient-specific three-dimensional finite element modeling

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Publisher
Springer Berlin Heidelberg
Copyright
Copyright © 2018 by International Federation for Medical and Biological Engineering
Subject
Biomedicine; Human Physiology; Biomedical Engineering; Imaging / Radiology; Computer Applications
ISSN
0140-0118
eISSN
1741-0444
D.O.I.
10.1007/s11517-018-1844-x
Publisher site
See Article on Publisher Site

Abstract

Vertebroplasty is a common and effective treatment for symptomatic osteoporotic vertebral compression fractures. However, the cemented and adjacent vertebras have a risk of recollapse due to largely unassured mechanisms, among which excessive stiffness of bone cement may be an important risk factor. This study aimed to find the most appropriate range of bone cement stiffness by analyzing its biomechanical effects on the augmented and adjacent vertebras of individual patient after vertebroplasty. A three-dimensional finite element model of T11-L1 osteoligamentous vertebras was reconstructed according to individual computed tomography data and validated by post mortem human subject experiment in literatures. Bone cement of varying stiffness was injected into the trabecular core of the T12 vertebra simulatively. The maximum von Mises stresses on cancellous and cortical bones of T11-L1 vertebras were analyzed under the loading conditions of flexion, extension, bending, and torsion. For the adjacent T11 and L1 vertebras, the stepwise elevation of the bone cement elastic modulus increased the maximum von Mises stress on the cancellous bone, but its effect on cortical bone was negligible. For the augmented T12 vertebra, the stresses on cancellous bone increased slightly under the loading condition of lateral bending and remained no impact on cortical bone.

Journal

Medical & Biological Engineering & ComputingSpringer Journals

Published: May 28, 2018

References

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