Optimisation of Cytoreductive Surgery in Relation to Ca 125
in Epithelial Ovarian Cancer
U. D. Bafna
Received: 5 January 2018 / Accepted: 24 January 2018 / Published online: 3 February 2018
Ó Association of Gynecologic Oncologists of India 2018
Background The ovarian cancer patients have good survival beneﬁt with optimal primary cytoreduction. Preoperative
evaluation with imaging and tumour markers for the possibility of optimisation has been routinely practiced. Imaging
though provides good insight about operability; the mesenteric, bowel and peritoneal surface diseases are not detected by
imaging. The present study evaluates the role of Ca 125 in detecting optimisation in primary cytoreduction.
Materials and Methods Prospective observational study of 194 patients of stage III epithelial ovarian cancer, with non-
mucinous histology, was analyzed for the Ca 125 level in relation to optimisation.
Results The statistical analysis of study results showed the p value of correlation between Ca 125 values, and residual
disease was 0.7 which was statistically not signiﬁcant.
Conclusion The results of the present study conclude that the serum Ca 125 levels do not correlate with the optimisation in
Keywords Optimal cyto reduction Á Tumour marker Á Residual disease Á Ovarian cancer
Ca 125 also known as MUC 16 (mucin 16) encoded by
MUC16 gene is an important tumour marker in epithelial
ovarian cancer management. Ca 125 was ﬁrst discovered
by Robert Bast in 1981. The serum level of Ca 125 levels is
used to aid in diagnosis, prognostication and during follow-
up for detection of recurrence. Though the level of Ca 125
is used in diagnosis and prognostication, the serum levels
of Ca 125 are nonspeciﬁc markers for both diagnosis and
prognosis. The Ca 125 values in epithelial ovarian cancer
are in wide range. Few patients have values in normal
range with few others having marked raise in the value of
tumour markers. The mucinous ovarian cancers are well
studied for their nature of expressing Ca 125 in low levels.
Even in serous and other histological tumours, the level of
expression of Ca 125 is not directly correlating to tumour
burden. The present study evaluates the role of Ca 125 as a
tumour marker in detecting the optimality in cytoreductive
surgeries for epithelial ovarian cancer.
To detect the correlation between serum Ca 125 levels and
the optimization in primary cytoreduction.
Materials and Methods
A prospective cohort of patients with primary ovarian
cancer admitted between January 2014 and March 2015
was included in the study.
& Natarajan Jayashree
U. D. Bafna
Department of Gynaecological Oncology, Kidwai Memorial
Institute of Oncology, Bangalore PIN-560029, India
Kidwai Memorial Institute of Oncology, Bangalore, India
MCh Gynaecological Oncology, Department of Obstetrics
and Gynaecology, All India Institute of Medical Sciences,
New Delhi PIN-110029, India
Indian Journal of Gynecologic Oncology (2018) 16:13