Background The ovarian cancer patients have good survival beneﬁt with optimal primary cytoreduction. Preoperative evaluation with imaging and tumour markers for the possibility of optimisation has been routinely practiced. Imaging though provides good insight about operability; the mesenteric, bowel and peritoneal surface diseases are not detected by imaging. The present study evaluates the role of Ca 125 in detecting optimisation in primary cytoreduction. Materials and Methods Prospective observational study of 194 patients of stage III epithelial ovarian cancer, with non- mucinous histology, was analyzed for the Ca 125 level in relation to optimisation. Results The statistical analysis of study results showed the p value of correlation between Ca 125 values, and residual disease was 0.7 which was statistically not signiﬁcant. Conclusion The results of the present study conclude that the serum Ca 125 levels do not correlate with the optimisation in cytoreduction. Keywords Optimal cyto reduction Tumour marker Residual disease Ovarian cancer Introduction prognosis. The Ca 125 values in epithelial ovarian cancer are in wide range. Few patients have values in normal Ca 125 also known as MUC 16 (mucin 16) encoded by range with few others having marked raise in the value of MUC16 gene
Indian Journal of Gynecologic Oncology – Springer Journals
Published: Feb 3, 2018
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