Optimisation of Cytoreductive Surgery in Relation to Ca 125 in Epithelial Ovarian Cancer

Optimisation of Cytoreductive Surgery in Relation to Ca 125 in Epithelial Ovarian Cancer Background The ovarian cancer patients have good survival benefit with optimal primary cytoreduction. Preoperative evaluation with imaging and tumour markers for the possibility of optimisation has been routinely practiced. Imaging though provides good insight about operability; the mesenteric, bowel and peritoneal surface diseases are not detected by imaging. The present study evaluates the role of Ca 125 in detecting optimisation in primary cytoreduction. Materials and Methods Prospective observational study of 194 patients of stage III epithelial ovarian cancer, with non- mucinous histology, was analyzed for the Ca 125 level in relation to optimisation. Results The statistical analysis of study results showed the p value of correlation between Ca 125 values, and residual disease was 0.7 which was statistically not significant. Conclusion The results of the present study conclude that the serum Ca 125 levels do not correlate with the optimisation in cytoreduction. Keywords Optimal cyto reduction  Tumour marker  Residual disease  Ovarian cancer Introduction prognosis. The Ca 125 values in epithelial ovarian cancer are in wide range. Few patients have values in normal Ca 125 also known as MUC 16 (mucin 16) encoded by range with few others having marked raise in the value of MUC16 gene http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Indian Journal of Gynecologic Oncology Springer Journals

Optimisation of Cytoreductive Surgery in Relation to Ca 125 in Epithelial Ovarian Cancer

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Publisher
Springer India
Copyright
Copyright © 2018 by Association of Gynecologic Oncologists of India
Subject
Medicine & Public Health; Oncology; Surgical Oncology
ISSN
2363-8397
eISSN
2363-8400
D.O.I.
10.1007/s40944-018-0181-1
Publisher site
See Article on Publisher Site

Abstract

Background The ovarian cancer patients have good survival benefit with optimal primary cytoreduction. Preoperative evaluation with imaging and tumour markers for the possibility of optimisation has been routinely practiced. Imaging though provides good insight about operability; the mesenteric, bowel and peritoneal surface diseases are not detected by imaging. The present study evaluates the role of Ca 125 in detecting optimisation in primary cytoreduction. Materials and Methods Prospective observational study of 194 patients of stage III epithelial ovarian cancer, with non- mucinous histology, was analyzed for the Ca 125 level in relation to optimisation. Results The statistical analysis of study results showed the p value of correlation between Ca 125 values, and residual disease was 0.7 which was statistically not significant. Conclusion The results of the present study conclude that the serum Ca 125 levels do not correlate with the optimisation in cytoreduction. Keywords Optimal cyto reduction  Tumour marker  Residual disease  Ovarian cancer Introduction prognosis. The Ca 125 values in epithelial ovarian cancer are in wide range. Few patients have values in normal Ca 125 also known as MUC 16 (mucin 16) encoded by range with few others having marked raise in the value of MUC16 gene

Journal

Indian Journal of Gynecologic OncologySpringer Journals

Published: Feb 3, 2018

References

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