J. Membrane Biol. 208, 89–90 (2005) DOI: 10.1007/s00232-005-0821-0 Thematic Issue B.M. Salzberg, Guest Editor Foreword B.M. Salzberg Departments of Neuroscience and Physiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA Received Received:: 1122 December December 2005 2005 More than three decades have passed since the of targeting an indicator to a selected subset of cells, introduction of potentiometric dyes for monitoring or to speciﬁc regions of cells. These authors also electrical activity in cells and tissues. At its inception, discuss one particularly elegant solution to this quest optical measurement of membrane potential prom- using, as a voltage-sensitive Fo¨ rster Resonance En- ised advantages under circumstances where electrodes ergy Transfer (FRET) acceptor, a highly mobile but were diﬃcult to use for reasons of size, complexity, or non-ﬂuorescent synthetic anion, dipicrylamine. The membrane topology. While many of these beneﬁts genetically targeted ﬂuorescence donor in this hybrid have been realized, what is most remarkable today is scheme is a modiﬁed eGFP that can be localized the number of applications that were not, or could exclusively to the inner leaﬂet of the plasma mem- not have been, anticipated. Many of these are to be brane. found in the papers contained in
The Journal of Membrane Biology – Springer Journals
Published: Jan 1, 2005
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