Objectives Idiopathic Burning mouth syndrome (iBMS) is a ference in salivary opiorphin levels between iBMS and con- poorly understood affection characterized by persistent pain in trols does not favor a direct local role for opiorphin in the the oral cavity without any clinical or biological abnormality. etiopathogeny of iBMS. However, higher blood opiorphin Opiorphin is a natural inhibitor of enkephalin-inactivating levels may reflect a systemic dysregulation in iBMS. ectopeptidases, mainly produced by salivary glands, that has Trial registration demonstrated analgesic properties. The objective of the pres- NCT02686359 https://clinicaltrials.gov/ct2 ent case-control study was to test the hypothesis of a decrease /show/NCT02686359 in opiorphin levels in iBMS patients. . . . Materials and methods Twenty-one iBMS patients and 21 Keywords Burning mouth syndrome Opiorphin Saliva . . matched controls subjects were included between 2011 and Blood Urine Pain 2013. Submandibular and sublingual salivary, blood, and uri- nary opiorphin levels of iBMS patients were compared to controls. Introduction Results Results are expressed as mean values ± SD and com- pared using the Wilcoxon Signed Rank test. Correlations were Idiopathic Burning Mouth Syndrome (iBMS) also called analyzed with Spearman coefficient. The level of significance stomatodynia is a poorly understood affection characterized was fixed
Clinical Oral Investigations – Springer Journals
Published: Nov 10, 2016
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